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ArtículoDerechos de autor
Acceso restringido
Fecha del embargo
2030-01-01
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- IOC - Artigos de Periódicos [12500]
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PROBABLE CORTICOSTEROID-INDUCED REACTIVATION OF LATENT HEPATITIS B VIRUS INFECTION IN AN HIV-POSITIVE PATIENT INVOLVING IMMUNE ESCAPE
Autor
Afiliación
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Infectious Diseases Unit. Lyon, France.
Hôpital de la Croix-Rousse. Virology Laboratory. Lyon, France.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Hepato-Gastroenterology Unit. Lyon, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Infectious Diseases Unit. Lyon, France.
Hôpital de la Croix-Rousse. Virology Laboratory. Lyon, France.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Hepato-Gastroenterology Unit. Lyon, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France.
Resumen en ingles
We describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor-based antiretroviral treatment, the patient developed an unexpected severe acute hepatitis despite persistence of anti-HBs. A genotype A2 strain emerged with 2 major mutations in the S gene, sK122R and sD144E. Molecular and biological analyses strongly suggested reactivation of a latent HBV infection. The importance and the molecular basis of these 2 epitopes in immune-escape mechanisms and host-virus interactions are discussed.
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