Author | Brito, Rita de Cássia Coelho Moraes de | |
Author | Lucena-Silva, Norma | |
Author | Torres, Leuridan Cavalcante | |
Author | Luna, Carlos Feitosa | |
Author | Correia, Jaílson de Barros | |
Author | Silva, Giselia Alves Pontes da | |
Access date | 2017-05-11T17:51:49Z | |
Available date | 2017-05-11T17:51:49Z | |
Document date | 2016 | |
Citation | BRITO, R. DE C. C. M. de et al. The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia. BMC Pulmonary Medicine, v. 16, n. 1, dez. 2016. | |
ISSN | 1471-2466 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/18830 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | The balance between the serum levels of IL-6 and IL-10 cytokines discriminates mild and severe acute pneumonia | pt_BR |
Type | Article | en |
DOI | 10.1186/s12890-016-0324-z | pt_BR |
Abstract | Background: To identify markers for earlier diagnosis of severe pneumonia, we assess the correlation between
serum cytokine profile of children with different pneumonia severity.
Methods: In 25 hospitalized children, 7 with mild pneumonia and 18 with severe pneumonia, the serum concentration
of 11 cytokines in three sampling times were dosed. Statistical analysis included parametric and non-parametric tests,
Pearson correlation and ROC curve for cut-off definition of cytokines.
Results: At admission, IL-6 serum levels were high in mild or severe pneumonia, and was associated to vomiting (P = 0.
019) in both groups; and also to dyspnea (P = 0.012) and white blood cell count (P = 0.045) in patients with severe
pneumonia. IL-10 levels were also high in patients with pneumonia and were associated to lymphocytosis (P = 0.025).
The ROC curve of the IL-6:IL-10 serum levels ratio discriminated severe pneumonia cases at admission, and persistence
of infection in the third day of antibiotic therapy, with positive predictive values of 93% and 89%, respectively.
Conclusions: The balance between IL-6 and IL-10 serum levels showed to be a more discriminative marker for severity
definition and evaluation of recovery in patients with pneumonia. | |
Affilliation | Institute of Integral Medicine Professor Fernando Figueira (IMIP). Pediatrics. Recife, PE, Brazil. | |
Affilliation | Institute of Integral Medicine Professor Fernando Figueira (IMIP). Oncology and Aggeu Magalhães Research Center. Fiocruz-PE. Immunology. Recife, PE, Brazil. | |
Affilliation | Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil. | |
Affilliation | Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Departamento de Saúde Pública. Recife, PE, Brasil. | |
Affilliation | Institute of Integral Medicine Professor Fernando Figueira ( IMIP). Translational Medicine Laboratory. Recife, PE, Brazil. | |
Affilliation | Federal University of Pernambuco. Pediatrics. Recife, PE, Brazil. | |
DeCS | Interleucina-10 / sangue | |
DeCS | Pneumonia / sangue | |
DeCS | Contagem de Leucócitos | |
DeCS | Biomarcadores / sangue | |
DeCS | Estudos Prospectivos | |