Description | Oliveira, Ricardo Riccio; Carvalho Filho, Edgar Marcelino “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
Candelaria Vergara1, Tanda Murray2, Nicholas Rafaels1, Rachel Lewis1, Monica Campbell1,
Cassandra Foster1, Li Gao1, Mezbah Faruque3, Ricardo Riccio Oliveira4, Edgar Carvalho4,
Maria Ilma Araujo4, Alvaro A. Cruz5, Harold Watson6, Dilia Mercado7, Jennifer Knight-
Madden8, Ingo Ruczinski9, Georgia Dunston3, Jean Ford2, Luis Caraballo7, Terri H. Beaty2,
Rasika A. Mathias1, and Kathleen C. Barnes1,* - 1Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University
(JHU), Baltimore, Maryland 2Department of Epidemiology, Bloomberg School of Public Health,
Johns Hopkins University, Baltimore, Maryland 3National Genome Center at Howard University,
Washington, DC 4Servico de Imunologia, Hospital Universitario Professor Edgard Santos,
Salvador, Bahia, Brazil 5ProAR – Nucleo de Excelencia em Asma, Federal University of Bahia
and CNPq, Salvador, Bahia, Brazil 6Faculty of Medicine, University of the West Indies, Cave Hill
Campus, Barbados 7Institute for Immunological Research, University of Cartagena, Cartagena,
Colombia 8Tropical Medicine Research Institute, The University of the West Indies, Jamaica,
West Indies 9Biostatistics, Bloomberg School of Public Health, Johns Hopkins University,
Baltimore, Maryland | pt_BR |
Abstract | Characterization of genetic admixture of populations in the Americas and the Caribbean is of interest for anthropological, epidemiological, and historical reasons. Asthma has a higher prevalence and is more severe in populations with a high African component. Association of African ancestry with asthma has been demonstrated. We estimated admixture proportions of samples from six trihybrid populations of African descent and determined the relationship between African ancestry and asthma and total serum IgE levels (tIgE). We genotyped 237 ancestry informative markers in asthmatics and nonasthmatic controls from Barbados (190/277), Jamaica (177/529), Brazil (40/220), Colombia (508/625), African Americans from New York (207/171), and African Americans from Baltimore/Washington, D.C. (625/757). We estimated individual ancestries and evaluated genetic stratification using Structure and principal component analysis. Association of African ancestry and asthma and tIgE was evaluated by regression analysis. Mean ± SD African ancestry ranged from 0.76 ± 0.10 among Barbadians to 0.33 ± 0.13 in Colombians. The European component varied from 0.14 ± 0.05 among Jamaicans and Barbadians to 0.26 ± 0.08 among Colombians. African ancestry was associated with risk for asthma in Colombians (odds ratio (OR) = 4.5, P = 0.001) Brazilians (OR = 136.5, P = 0.003), and African Americans of New York (OR: 4.7; P = 0.040). African ancestry was also associated with higher tIgE levels among Colombians (β = 1.3, P = 0.04), Barbadians (β = 3.8, P = 0.03), and Brazilians (β = 1.6, P = 0.03). Our findings indicate that African ancestry can account for, at least in part, the association between asthma and its associated trait, tIgE levels. | pt_BR |