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Autor | Domingos, João Américo | |
Autor | Soares, Luana Silva | |
Autor | Bandeira, Larissa M. | |
Autor | Bonin, Camila Mareti | |
Autor | Vicente, Ana C. P. | |
Autor | Zanella, Louise | |
Autor | Puga, Marco Antonio Moreira | |
Autor | Tozetti, Inês Aparecida | |
Autor | Castro, Ana Rita Coimbra Motta | |
Autor | Cunha, Rivaldo Venâncio da | |
Fecha de acceso | 2017-07-06T11:14:44Z | |
Fecha de disponibilización | 2017-07-06T11:14:44Z | |
Fecha de publicación | 2017 | |
Referencia | DOMINGOS, João Américo; et al. Cytokine profile and proviral load among Japanese immigrants and non-Japanese infected with HTLV-1 in a non-endemic area of Brazil. Plos One, v.12, n.4, e0174869, Apr. 2017. | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/19733 | |
Idioma | eng | pt_BR |
Editor | Public Library of Science | pt_BR |
Derechos de autor | open access | pt_BR |
Palabras clave en Portugués | Citocinas | pt_BR |
Palabras clave en Portugués | Carga proviral | pt_BR |
Palabras clave en Portugués | Imigrantes janponeses | pt_BR |
Palabras clave en Portugués | Não japoneses | pt_BR |
Palabras clave en Portugués | Infecção | pt_BR |
Palabras clave en Portugués | Áreas não endêmicas | pt_BR |
Palabras clave en Portugués | Brasil | pt_BR |
Palabras clave en Portugués | Vírus 1 Linfotrópico T Humano | pt_BR |
Título | Cytokine profile and proviral load among Japanese immigrants and non-Japanese infected with HTLV-1 in a non-endemic area of Brazil | pt_BR |
Tipo del documento | Article | pt_BR |
DOI | 10.1371/journal.pone.0174869 | |
Resumen en Inglés | The lifetime risk of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) development differs among ethnic groups. To better understand these differences, this prospective cohort study was conducted to investigate the cytokine profile and the HTLV-1 proviral load (PVL) in Japanese and non-Japanese populations with HAM/TSP and asymptomatic carriers (ACs). The serum IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, and IFN-γ levels were quantified using the Cytometric Bead Array in 40 HTLV-1-infected patients (11 HAM/TSP and 29 ACs) and 18 healthy controls (HCs) in Brazil. Among ACs, 15 were Japanese descendants and 14 were non-Japanese. Of 11 patients with HAM/TSP, only one was a Japanese descendant. The HTLV-1 PVL was quantified by real-time PCR. The HTLV-1 PVL was 2.7-fold higher in HAM/TSP patients than ACs. Regardless of the clinical outcome, the PVL was significantly higher in patients younger than 60 years than older patients. The HAM/TSP and ACs had higher IL-10 serum concentrations than that of HCs. The ACs also showed higher IL-6 serum levels than those of HCs. According to age, the IL-10 and IL-6 levels were higher in ACs non-Japanese patients older than 60 years. HAM/TSP patients showed a positive correlation between IL-6 and IL-17 and a negative correlation between the PVL and IL-17 and IFN-γ. In the all ACs, a significant positive correlation was observed between IL-2 and IL-17 and a negative correlation was detected between IL-10 and TNF-α. Only 6.25% of the Japanese patients were symptomatic carriers, compared with 41.67% of the non-Japanese patients. In conclusion, this study showed that high levels of HTLV-1 PVL was intrinsicaly associated with the development of HAM/TSP. A higher HTLV-1 PVL and IL10 levels found in non-Japanese ACs over 60 years old, which compared with the Japanese group depicts that the ethnic background may interfere in the host immune status. More researches also need to be undertaken regarding the host genetic background to better understand the low frequency of HAM/TSP in Japanese HTLV-1-infected individuals. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil. | pt_BR |
Afiliación | Universidade Federal de Mato Grosso do Sul. Campo Grande, MS, Brasil / Fundação Oswaldo Cruz. Campo Grande, MS, Brasil. | pt_BR |
Palavras clave en Inglês | Cytokine profile | pt_BR |
Palavras clave en Inglês | Japanese immigrants | pt_BR |
Palavras clave en Inglês | non-Japanese | pt_BR |
Palavras clave en Inglês | HTLV-1 | pt_BR |
Palavras clave en Inglês | Brazil | pt_BR |
Palavras clave en Inglês | proviral load | pt_BR |
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