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CUTANEOUS MANIFESTATIONS OF HUMAN AND MURINE LEISHMANIASIS
Leishmaniose cutânea
Leishmaniose mucosa
Leishmaniose difusa
Leishmaniose disseminada
Pele
Kala-azar
Imunologia
Cutaneous leishmaniasis
Mucosal leishmaniasis
Diffuse leishmaniasis
Disseminated leishmaniasis
DTH-delayed type hypersensitivity skin test
LST-Leishmania skin test
Post-kala-azar dermal leishmaniasis
Kala-azar
Skin immunology
Afiliación
University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil
University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA / University of Iowa. Department of Internal Medicine. Iowa City, IA, USA / University of Iowa. Department of Microbiology. Iowa City, IA, USA / Veterans’ Affairs Medical Center. Iowa City, IA, USA
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Salvador, BA, Brasil
University of Iowa. Interdisciplinary Graduate Program in Immunology. Iowa City, IA, USA / University of Iowa. Department of Internal Medicine. Iowa City, IA, USA / University of Iowa. Department of Microbiology. Iowa City, IA, USA / Veterans’ Affairs Medical Center. Iowa City, IA, USA
Resumen en ingles
The leishmaniases are diseases caused by pathogenic protozoan parasites of the genus Leishmania. Infections are initiated when a sand fly vector inoculates Leishmania parasites into the skin of a mammalian host. Leishmania causes a spectrum of inflammatory cutaneous disease manifestations. The type of cutaneous pathology is determined in part by the infecting Leishmania species, but also by a combination of inflammatory and anti-inflammatory host immune response factors resulting in different clinical outcomes. This review discusses the distinct cutaneous syndromes described in humans, and current knowledge of the inflammatory responses associated with divergent cutaneous pathologic responses to different Leishmania species. The contribution of key hematopoietic cells in experimental cutaneous leishmaniasis in mouse models are also reviewed and compared with those observed during human infection. We hypothesize that local skin events influence the ensuing adaptive immune response to Leishmania spp. infections, and that the balance between inflammatory and regulatory factors induced by infection are critical for determining cutaneous pathology and outcome of infection.
Palabras clave en portugues
LeishmaniaLeishmaniose cutânea
Leishmaniose mucosa
Leishmaniose difusa
Leishmaniose disseminada
Pele
Kala-azar
Imunologia
Palabras clave en ingles
LeishmaniaCutaneous leishmaniasis
Mucosal leishmaniasis
Diffuse leishmaniasis
Disseminated leishmaniasis
DTH-delayed type hypersensitivity skin test
LST-Leishmania skin test
Post-kala-azar dermal leishmaniasis
Kala-azar
Skin immunology
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