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https://www.arca.fiocruz.br/handle/icict/20379
A THREE YEAR FOLLOW-UP OF CHEMOTHERAPY WITH OXAMNIQUINE IN A BRAZILIAN COMMUNITY WITH ENDEMIC SCHISTOSOMIASIS MANSONI
Quimioterapia
Oxamniquine
Prevalência
Humanos
Tratamento
Author
Affilliation
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brazil
Universidade Federal da Bahia. Departamento de Medicina Preventiva. Salvador, BA, Brasil
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Sem afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Bahia. Salvador, BA, Brazil
Universidade Federal da Bahia. Departamento de Medicina Preventiva. Salvador, BA, Brasil
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Harvard School of Public Health. Department of Tropical Public Health. Boston, MA, USA
Sem afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract
Oral oxamniquine was tested as a control strategy
for endemic schistosomiasis in a rural area of
Bahia, Brazil. Adults were treated with a single
dose (12 * 5 to 15 mg per kg) and children ( < 12
years old) with a total of 20 mg per kg in two doses.
The 191 (infected) persons treated represented
69% of the infected population in the study area.
Follow-up stool examinations (Kato-Katz method)
at one, 3, 6,13,25 and 33 months showed the cure
rate declining from 80% at three months to 46%
at 33 months. Over one half of those not cured
showed a decrease in egg counts throughout the
follow-up which, after 33 months, remained
66% below the pre-treatment levels. Stool examinations
conducted on all study area residents
during three years before chemotherapy showed
the prevalence and intensity of Schistosoma mansoni
infection to be high and stable. 33 months after
the chemotherapy the prevalence was 41% and for
infected individuals the geometric mean egg count
was 121 epg, a decline of respectively 35y0 and
4074 from pre-treatment levels for each index.
Chemotherapy of infected persons with oxamniquine
protected the community as a whole from high
worm burdens for almost three years, although at
this point the prevalence began to rise towards
pretreatment levels.
Keywords in Portuguese
Esquistossomose mansoniQuimioterapia
Oxamniquine
Prevalência
Humanos
Tratamento
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