Author | Brodskyn, Claudia Ida | |
Author | Silva, Ana Maria Moura da | |
Author | Takehara, Harumi Ando | |
Author | Albuquerque, Ivan da Mota e | |
Access date | 2017-07-26T18:38:42Z | |
Available date | 2017-07-26T18:38:42Z | |
Document date | 1989 | |
Citation | BRODSKYN, C. I. et al. IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi. Immunology and Cell Biology, v. 67, p. 343-348, 1989. | pt_BR |
ISSN | 0818-9641 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20418 | |
Description | Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Language | eng | pt_BR |
Publisher | Nature Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | IgG | pt_BR |
Subject in Portuguese | Soro | pt_BR |
Subject in Portuguese | Imunoglobulina | pt_BR |
Subject in Portuguese | Infecção | pt_BR |
Title | IgG subclasses responsible for immune clearance in mice infected with Trypanosoma cruzi | pt_BR |
Type | Article | pt_BR |
Abstract | To examine the role of different immunoglobulin subclasses in the immune clearance of
Trypanosoma cruzi, mice containing bloodstream trypomastigotes were injeeted intravenously with
immune serum, IgG-depleted serum, or with thelgGI or IgG2 fraelionsand the rateof removal of the
parasites from circulation was determined. Using IgG concentrations similar to those found in the
immune serum, the rate of clearanee mediated by IgG2 was six-fold higher than that obtained with
IgGI. This differenee did not appear to be due to differences in antibody specificity, as Western
blotting showed that each isotype recognized a similar set of antigens extracted from the parasite.
However, the T. cruzi specific antibody content of the IgG2 was approximately five-fold higher than
IgG I - When the dose of IgG was adjusted to equalize the antibody content, the clearance ability of the
IgGI and IgG2 was very similar. It is concluded Ihat the two subclasses have a similar clearance
ability. | pt_BR |
Affilliation | Institulo Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Affilliation | Institulo Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Health Sciences Institute. Laboratory of Immunology and Molecular Biology. Bioaggression Department. Salvador, BA, Brazil | pt_BR |
Affilliation | Federal University of Bahia. Health Sciences Institute. Laboratory of Immunology and Molecular Biology. Bioaggression Department. Salvador, BA, Brazil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | IgG | pt_BR |
Subject | Serum | pt_BR |
Subject | Immunoglobulin | pt_BR |
Subject | Infection | pt_BR |