Author | Takehara, Harumi Ando | |
Author | Silva, Ana Maria Moura da | |
Author | Brodskyn, Claudia Ida | |
Author | Mota, Ivan | |
Access date | 2017-07-27T17:43:03Z | |
Available date | 2017-07-27T17:43:03Z | |
Document date | 1989 | |
Citation | TAKEHARA, H. A. et al. A comparative study of anti-Trypanosoma cruzi serum obtained in acute and chronic phase of infection in mice. Immunology Letters, v. 23, n. 2, p. 81-86, 1989/1990-. | pt_BR |
ISSN | 0165-2478 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20429 | |
Description | Brodskyn, Claudia Ida “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Language | eng | pt_BR |
Publisher | European Federation of Immunological Societies | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | IgG | pt_BR |
Subject in Portuguese | Anticorpo | pt_BR |
Subject in Portuguese | Imunidade | pt_BR |
Title | A comparative study of anti-Trypanosoma cruzi serum obtained in acute and chronic phase of infection in mice | pt_BR |
Type | Article | pt_BR |
Abstract | The IgG antibody content, specificity, lytic activity,
clearance capacity and protective ability of
mouse anti-Trypanosoma cruzi serum was determined
during the course of infection. The IgG antibody
content increased during the course of infection,
reaching its highest level in the serum collected
in the chronic phase of the infection. The T. cruzi antigens
recognized by antibodies using the protein
transfer technique also increased with time of infection.
Antibodies present in day 22 post-infection
(p.i.) serum were already able to recognize all the antigens
detected by antibodies present in serum from
the chronic phase. The lytic and clearance ability
were not detected on day 7 p.i., but appeared on day
14 p.i. and reached their highest level on day 45 p.i.
The protective ability was present in serum of the
chronic phase, but was absent from the acute serum.
The IgG antibody content of the acute serum was
four times less than that of the chronic serum. When
the IgG antibody concentration of the acute serum
was equalized to that of the chronic serum, the acute
serum was as able to protect the infected animals as
the chronic serum. It is suggested that the disagreement
between the protective ability of anti-T, cruzi
antisera collected in the acute or in the chronic phase
of the infection is due to a quantitative rather than
a qualitative difference. | pt_BR |
Affilliation | Instituto Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Affilliation | Instituto Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Affilliation | Instituto Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Affilliation | Instituto Butantan. Immunology Research and Training Center. São Paulo, SP, Brazil | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | IgG anti-T. cruzi | pt_BR |
Subject | Antibody | pt_BR |
Subject | Immunity | pt_BR |