Author | Machado, Paulo Roberto Lima | |
Author | Rosa, Maria Elisa Alves | |
Author | Guimarães, Luís Henrique Santos | |
Author | Prates, Fernanda Ventim de Oliveira | |
Author | Queiroz, Adriano | |
Author | Schriefer, Albert | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2017-08-08T17:20:42Z | |
Available date | 2017-08-08T17:20:42Z | |
Document date | 2015 | |
Citation | MACHADO, P. R. L. et al. Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B. Clinical Infectious Diseases, v. 61, p. 945-949, 2015. | pt_BR |
ISSN | 1058-4838 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20542 | |
Description | Carvalho Filho, Edgar Marcelino de “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Ministry of Health of Brazil (MS) and the National Council of Scientific and Technological Development (CNPq) [Edital MS-SCIET-DECIT/CNPq No 69/2010]. | pt_BR |
Language | eng | pt_BR |
Publisher | Oxfor University Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose tegumentar americana | pt_BR |
Subject in Portuguese | Leishmaniose | pt_BR |
Subject in Portuguese | Anfotericina B | pt_BR |
Title | Treatment of Disseminated Leishmaniasis With Liposomal Amphotericin B | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/cid/civ416 | |
Abstract | Disseminated leishmaniasis (DL) is a severe and emerging form of American tegumentary leishmaniasis, associated primarily with infection by Leishmania brasiliensis. DL is defined by the presence of ≥10 mixed-type lesions such as inflammatory papules and ulcers, located in ≥2 body parts. Most patients have hundreds of lesions all over the body, and mucosal involvement is detected in up to 44% of cases. DL is a difficult to cure disease and pentavalent antimony (Sb(v)) is used as standard treatment, its highest dosage being 20 mg/kg/day, for 30 days. However, less than 25% of DL cases will be cured after standard therapy, and the majority of cases will require more than one course of Sb(v) for a cure. In this context, new therapies are needed that offer a higher cure rate and a better safety profile, with convenience in drug administration. Methods. We have evaluated liposomal amphotericin B in 20 patients with DL in an open clinical trial. The total
dose ranged from 17 to 37 mg/kg, used in 7 to 14 days of treatment.
Results. Cure rate at 3 months after therapy was 70%. One relapse was documented 4 months after treatment,
producing a final cure rate of 65%. Although liposomal amphotericin B was considered well tolerated, mild adverse
events were documented in 75% of the patients.
Conclusions. Liposomal amphotericin B is an effective therapy for DL, with a higher final cure rate of 75%
observed when used in a total dose above 30 mg/kg. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia de Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Subject | American tegumentary leishmaniasis | pt_BR |
Subject | Disseminated leishmaniasis | pt_BR |
Subject | Liposomal amphotericin B | pt_BR |