Author | Pacheco, Sidelcina Rugieri | |
Author | Santos, Maria Isabel Magalhães Andrade dos | |
Author | Stocker, Andreas | |
Author | Zarife, Maria Alice Sant'Anna | |
Author | Schinoni, Maria Isabel | |
Author | Paraná, Raymundo | |
Author | Reis, Mitermayer Galvão dos | |
Author | Silva, Luciano Kalabric | |
Access date | 2017-08-16T16:39:09Z | |
Available date | 2017-08-16T16:39:09Z | |
Document date | 2017 | |
Citation | PACHECO, S. R. et al. Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B. Infection and Drug Resistance, jul. 2017. | pt_BR |
ISSN | 1178-6973 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20642 | |
Sponsorship | Program for Technological Development in Tools for Health (PDTIS), Fiocruz, the workers from LACENBA,
LACEN-AC, and Fundação Hospitalar do Acre (Fundhacre). Funding support was provided by the National Counsel of Technological and Scientific Development (CNPq) process 478322/2012-7 and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) “Brasil sem Miséria” (BSM, Brazil without Misery) | pt_BR |
Language | eng | pt_BR |
Publisher | Dove Medical Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Nordeste | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | Sequenciação direta | pt_BR |
Subject in Portuguese | Falha de tratamento | pt_BR |
Title | Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B | pt_BR |
Type | Article | pt_BR |
DOI | 10.2147/IDR.S135420 | |
Abstract | Resistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naïve to chronic hepatitis B, in the Northern and Northeastern regions of Brazil. Methods: We conducted a study of resistance mutations and genotypic characterization of
hepatitis B virus (HBV) in 189 treatment-naïve patients chronically infected with HBV.
Results: Drug resistance-associated mutations located in the RT domain of the P gene (rtHBV)
were found in 6% of the treatment-naïve patients from the Northeastern Region. The mutations
were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and rtA181S. No patient in the Northern
Region had the resistance mutation. In the gene S region, the frequency of vaccine escape mutations
was 2.4% in the Northeastern Region and 8.6% in the Northern Region.
Conclusion: This information before the start of treatment may contribute to clinical decision
making, reducing treatment failure and the risk of progression to cirrhosis and hepatocellular
carcinoma for CHB. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Central Laboratory of Public Health of Bahia. Salvador, BA, Brazil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Subject | Northeast | pt_BR |
Subject | Brazil | pt_BR |
Subject | Direct sequencing | pt_BR |
Subject | Treatment failure | pt_BR |