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ANTITUMOUR PROPERTIES OF THE LEAF ESSENTIAL OIL OF XYLOPIA FRUTESCENS AUBL. (ANNONACEAE)
Annonaceae
Óleo essencial
Composição química
Antitumour
Annonaceae
Essential oil
Chemical composition
Antitumour
Autor
Afiliación
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Resumen en ingles
The aim of this study was to investigate the chemical composition and anticancer effect of the leaf essential oil of Xylopia frutescens in experimental models. The chemical composition of the essential oil was analysed by GC/FID and GC/MS. In vitro cytotoxic activity of the essential oil was determined on cultured tumour cells. In vivo antitumour activity was assessed in Sarcoma 180-bearing mice. The major compounds identified were (E)-caryophyllene (31.48%), bicyclogermacrene (15.13%), germacrene D (9.66%), δ-cadinene (5.44%), viridiflorene (5.09%) and α-copaene (4.35%). In vitro study of the essential oil displayed cytotoxicity on tumour cell lines and showed IC50 values ranging from 24.6 to 40.0 μg/ml for the NCI-H358M and PC-3M cell lines, respectively. In the in vivo antitumour study, tumour growth inhibition rates were 31.0-37.5%. In summary, the essential oil was dominated by sesquiterpene constituents and has some interesting anticancer activity.
Palabras clave en portugues
Xylopia frutescensAnnonaceae
Óleo essencial
Composição química
Antitumour
Palabras clave en ingles
Xylopia frutescensAnnonaceae
Essential oil
Chemical composition
Antitumour
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