Author | Frabasile, Sandra | |
Author | Koishi, Andrea Cristine | |
Author | Kuczera, Diogo | |
Author | Silveira, Guilherme Ferreira | |
Author | Verri Jr, Waldiceu Aparecido | |
Author | Santos, Claudia Nunes Duarte dos | |
Author | Bordignon, Juliano | |
Access date | 2017-08-28T15:15:54Z | |
Available date | 2017-08-28T15:15:54Z | |
Document date | 2017 | |
Citation | FRABASILE, Sandra et al. The citrus flavanone naringenin impairs dengue virus replication in human cells. Scientific Reports, v. 7, n.41864, 2017. | pt_BR |
ISSN | 2045-2322 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20779 | |
Language | por | pt_BR |
Publisher | Nature Publishing Group | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Dengue | pt_BR |
Title | The citrus flavanone naringenin impairs dengue virus replication in human cells | pt_BR |
Type | Article | pt_BR |
DOI | https://doi.org/10.1038/srep41864 | |
Abstract | Dengue is one of the most significant health problems in tropical and sub-tropical regions throughout the world. Nearly 390 million cases are reported each year. Although a vaccine was recently approved in certain countries, an anti-dengue virus drug is still needed. Fruits and vegetables may be sources of compounds with medicinal properties, such as flavonoids. This study demonstrates the anti-dengue virus activity of the citrus flavanone naringenin, a class of flavonoid. Naringenin prevented infection with four dengue virus serotypes in Huh7.5 cells. Additionally, experiments employing subgenomic RepDV-1 and RepDV-3 replicon systems confirmed the ability of naringenin to inhibit dengue virus replication. Antiviral activity was observed even when naringenin was used to treat Huh7.5 cells 24 h after dengue virus exposure. Finally, naringenin anti-dengue virus activity was demonstrated in primary human monocytes infected with dengue virus sertoype-4, supporting the potential use of naringenin to control dengue virus replication. In conclusion, naringenin is a suitable candidate molecule for the development of specific dengue virus treatments. | pt_BR |
Affilliation | Facultad de Ciencias, Universidad de La República. Sección Virologia. Montevideo, Uruguay. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Londrina, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil. | pt_BR |
Subject | Antiviral Agents | pt_BR |
Subject | Flavonoids | pt_BR |
Subject | Flavanones | pt_BR |
Subject | Dengue Virus | pt_BR |
Subject in Spanish | Antivirales | pt_BR |
Subject in Spanish | Flavonoides | pt_BR |
Subject in Spanish | Flavanonas | pt_BR |
Subject in Spanish | Virus del Dengue | pt_BR |
DeCS | Antivirais | pt_BR |
DeCS | Flavonoides | pt_BR |
DeCS | Flavanonas | pt_BR |
DeCS | Vírus da Dengue | pt_BR |