Author | Fernandes, Christiane | |
Author | Horn, Adolfo | |
Author | Motta, Olney Vieira da | |
Author | Assis, Vagner M. de | |
Author | Rocha, Michelle R. | |
Author | Mathias, Luciana da S. | |
Author | Bull, Erika S. | |
Author | Bortoluzzi, Adailton J. | |
Author | Guimarães, Erick Vaz | |
Author | Almeida, João Carlos Aquino | |
Author | Russell, David H. | |
Access date | 2017-09-05T12:21:51Z | |
Available date | 2017-09-05T12:21:51Z | |
Document date | 2010 | |
Citation | FERNANDES, Christiane; et al. Synthesis, characterization and antibacterial activity of FeIII, CoII, CuII and ZnII complexes probed by transmission electron microscopy. Journal of Inorganic Biochemistry v.104, p.1214–1223, 2010. | pt_BR |
ISSN | 0162-0134 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/20910 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Raios X | pt_BR |
Subject in Portuguese | Microscopia Eletrônica de Transmissão | pt_BR |
Subject in Portuguese | Atividade antibacteriana | pt_BR |
Subject in Portuguese | Espectrometria de Massas por Ionização por Electrospray | pt_BR |
Title | Synthesis, characterization and antibacterial activity of FeIII, CoII, CuII and ZnII complexes probed by transmission electron microscopy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.jinorgbio.2010.07.011 | |
Abstract | We synthesized iron(III), cobalt(II), copper(II) and zinc(II) complexes [Fe(III)(HBPClNOL)Cl(2)]·H(2)O (1), [Co(II)(H(2)BPClNOL)Cl(2)] (2), [Cu(II)(H(2)BPClNOL)Cl]Cl·H(2)O (3), and [Zn(II)(HBPClNOL)Cl] (4), where H(2)BPClNOL is the ligand (N-(2-hydroxybenzyl)-N-(2-pyridylmethyl)[(3-chloro)(2-hydroxy)]propylamine). The complexes obtained were characterized by elemental analysis, IR and UV-visible spectroscopies, electrospray ionization mass spectrometry (ESI-MS), tandem mass spectrometry (MS/MS), and cyclic voltammetry. X-ray diffraction studies were performed for complexes (3) and (4) revealing the presence of mononuclear and dinuclear structures in solid state for (3). However, the zinc complex is mononuclear in solid state. Biological studies of complexes (1)-(4) were carried out in vitro for antimicrobial activity against nine Gram-positive bacteria (Staphylococcus aureus strains RN 6390B, COL, ATCC 25923, Smith Diffuse, Wood 46, enterotoxigenic S. aureus FRI-100 (SEA+), FRI S-6 (SEB+) and SEC FRI-361) and animal strain S. aureus LSA 88 (SEC/SED/TSST-1+). The following sequence of inhibition promoted by the complexes was observed: (4)>(2)>(3)>(1), showing the effect of the metal on the biological activity. To directly observe the morphological changes of the internal structure of bacterial cells after the treatment, transmission electron microscopy (TEM) was employed. For the most active complex [Zn(II)(HBPClNOL)Cl] (4), granulation deposits around the genetic material and internal material leaking were clearly detected. | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Ciências Químicas. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Ciências Químicas. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Sanidade Animal. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Ciências Químicas. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Ciências Químicas. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Sanidade Animal. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Ciências Químicas. Campos de Goytacazes, RJ, Brasil | pt_BR |
Affilliation | Universidade Federal de Santa Catarina. Departamento de Química. Florianópolis, SC, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Estrutural. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense. Laboratório de Fisiologia e Bioquímica de Microrganismos. Campos de Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Texas A&M University. Chemistry Department. Laboratory for Biological Mass Spectrometry. College Station, Texas, USA. | pt_BR |
Subject | FeIII, CoII, CuII, ZnII complex | pt_BR |
Subject | Antibacterial activity | pt_BR |
Subject | S. aureus | pt_BR |
Subject | ESI-MS/MS | pt_BR |
Subject | X-ray | pt_BR |
Subject | Transmission electron microscopy | pt_BR |
e-ISSN | 1873-3344 | |
Embargo date | 2030-01-01 | |