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https://www.arca.fiocruz.br/handle/icict/20954
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ArtigoDireito Autoral
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- IOC - Artigos de Periódicos [12495]
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RECOMBINANT YELLOW FEVER VACCINE VIRUS 17D EXPRESSING SIMIAN IMMUNODEFICIENCY VIRUS SIVMAC239 GAG INDUCES SIV-SPECIFIC CD8+ T-CELL RESPONSES IN RHESUS MACAQUES
Vaccine
Rhesus Macaques
Immunodeficiency Virus
CD8 T cells
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
Resumo em Inglês
Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8(+) T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8(+) T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIV-specific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells.
Palavras-chave em inglês
Yellow Fever Virus 17DVaccine
Rhesus Macaques
Immunodeficiency Virus
CD8 T cells
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