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Autor | Amaral, Eduardo Pinheiro | |
Autor | Andrade, Bruno de Bezerril | |
Fecha de acceso | 2017-09-25T17:59:16Z | |
Fecha de disponibilización | 2017-09-25T17:59:16Z | |
Fecha de publicación | 2017 | |
Referencia | AMARAL, E. P.; ANDRADE, B. B. Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection. Clinical Medicine Insights: Case Reports, v. 9, p. 1-10, 2017. | pt_BR |
ISSN | 1178-6450 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/21099 | |
Idioma | eng | pt_BR |
Editor | Libertas Academica | pt_BR |
Derechos de autor | open access | pt_BR |
Palabras clave en Portugués | Mycobactérias | pt_BR |
Palabras clave en Portugués | Sensores | pt_BR |
Palabras clave en Portugués | NF-κappa B | pt_BR |
Palabras clave en Portugués | Hospedeiro | pt_BR |
Palabras clave en Portugués | Mycobacterium tuberculosis | pt_BR |
Título | Nuclear Factor κB Activation Pathways During Mycobacterium tuberculosis Infection | pt_BR |
Tipo del documento | Article | pt_BR |
Resumen en Inglés | The interactions between pathogens and host cells and the way by which the immune response is modulated during this process ultimately dictate the fate of infection. Host phagocytes exposed to Mycobacterium tuberculosis (M. tuberculosis) sense microbial-associated molecular patterns and activate a series of signaling pathways. In this setting, activation of the nuclear factor κB (NF-κB) initiates transcription of several key genes involved in orchestration of antimycobacterial effector functions. This review describes these major pathways that govern the outcome of host phagocytes infected with M. tuberculosis. Furthermore, we highlight evidence of how M. tuberculosis modulates activation of NF-κB pathways to evade the host antimycobacterial defense. | pt_BR |
Afiliación | National Institutes of Health. National Institute of Allergy and Infectious Diseases. Laboratory of Parasitic Diseases. Immunobiology Section. Bethesda, MD, USA / University of São Paulo. Institute of Biomedical Sciences. Laboratory of Immunology of Infectious Diseases. Department of Immunology. São Paulo, SP, Brazil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brazil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research Initiative. Salvador, BA, Brazil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brazil | pt_BR |
Palavras clave en Inglês | Mycobacteria | pt_BR |
Palavras clave en Inglês | Immune sensors | pt_BR |
Palavras clave en Inglês | NF-κB pathways | pt_BR |
Palavras clave en Inglês | Host defense | pt_BR |
Palavras clave en Inglês | Mycobacterium tuberculosis | pt_BR |