Author | Xavier, Aurelizia Maria Lemos | |
Author | Magalhães, Jorge André Sacramento | |
Author | Cunha, Gisele dos Santos Pessanha | |
Author | Silva, Antonio Carlos | |
Author | Tavares, Daniel Augusto Gonçalves | |
Author | Silva, Maria de Fátima Sarro da | |
Author | Moraes Neto, Antonio Henrique Almeida de | |
Access date | 2017-09-26T13:36:56Z | |
Available date | 2017-09-26T13:36:56Z | |
Document date | 2010 | |
Citation | XAVIER, Aurelizia Maria Lemos; et al. Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice. Avta Tropioca, v.116, p.95-99, 2010. | pt_BR |
ISSN | 0001-706X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/21108 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Schistosoma mansoni | pt_BR |
Subject in Portuguese | Ultraestrutura | pt_BR |
Subject in Portuguese | Microscopia Eletrônica de Varredura | pt_BR |
Subject in Portuguese | Camundongos | pt_BR |
Subject in Portuguese | Tegumento | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Subject in Portuguese | Tolerância oral | pt_BR |
Title | Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.actatropica.2010.06.004 | |
Abstract | The present study exhibits original results of S. mansoni tegumental alterations due to contact with the immune system of non anti-helminthic treated mice. We compared, by SEM, the tegument of adult worms recovered from strains of mice genetically selected to extreme phenotypes of resistance (TR strain) and susceptibility (TS strain) to egg-albumin oral tolerance (OT). The parasites recovered from TR mice displayed no morphologic alteration, while specimens collected from TS mice presented tubercle swelling with blunted and shortened spines in lower density, increased sensory organelle numbers, fusion and tegumental ridge peeling. These tegument alterations were similar to those described for Artemether or Praziquantel treatment, supporting observations that the host immune system influences the development and function of the tegument of worms harbored in both anti-helminthic treated and non-treated mice. Our results are indicative that the development and function of the worm tegument depend on the immune regulatory capacity of each individual host. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Imunobiologia. Niterói, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Departamento de Genérica. Laboratório de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense Darcy Ribeiro. Centro de Biociências e Biotecnologia. Laboratório de Biologia Celular e Tecidual. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense Darcy Ribeiro. Centro de Biociências e Biotecnologia. Laboratório de Biologia Celular e Tecidual. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Departamento de Genérica. Laboratório de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade do Estado do Rio de Janeiro. Instituto de Biologia. Departamento de Genérica. Laboratório de Imunobiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Estadual do Norte Fluminense Darcy Ribeiro. Centro de Biociências e Biotecnologia. Laboratório de Biologia Celular e Tecidual. Campos dos Goytacazes, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ecoepidemiologia e Controle da Esquistossomose e Geohelmintoses. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Schistosoma mansoni | pt_BR |
Subject | Tegument | pt_BR |
Subject | Ultrastructure | pt_BR |
Subject | Scanning electron microscopy | pt_BR |
Subject | Immune response | pt_BR |
Subject | Oral tolerance | pt_BR |
Subject | Mice | pt_BR |
e-ISSN | 1873-6254 | |
Embargo date | 2030-01-01 | |