Author | Starling, Ana Lúcia Borges | |
Author | Reis, Jordana Grazziela Alves Coelho dos | |
Author | Pascoal, Vanessa Peruhype Magalhães | |
Author | Xavier, Marcelo Antônio Pascoal | |
Author | Gonçalves, Denise Utsch | |
Author | Béla, Samantha Ribeiro | |
Author | Lambertucci, José Roberto | |
Author | Labanca, Ludimila | |
Author | Pereira, Silvio Roberto Souza | |
Author | Carvalho, Andréa Teixeira de | |
Author | Ribas, João Gabriel | |
Author | Trindade, Bruno Caetano | |
Author | Faccioli, Lúcia Helena | |
Author | Proietti, Anna Bárbara Freitas Carneiro | |
Author | Martins Filho, Olindo Assis | |
Access date | 2018-01-30T16:36:33Z | |
Available date | 2018-01-30T16:36:33Z | |
Document date | 2015 | |
Citation | STARLING, Ana Lúcia Borges et al. Immunological signature of the different clinical stages of the HTLV-1 infection: establishing serum biomarkers for HTLV-1-associated disease morbidity. Biomarkers, v. 20, n. 6-7, p. 502-512, 2015. | pt_BR |
ISSN | 1354-750X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24192 | |
Language | eng | pt_BR |
Publisher | Tayor & Francis | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HAM/TSP | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Title | Immunological signature of the different clinical stages of the HTLV-1 infection: establishing serum biomarkers for HTLV-1-associated disease morbidity | pt_BR |
Type | Article | pt_BR |
DOI | 10.3109/1354750X.2015.1094141 | |
Abstract | This study aimed at establishing the immunological signature and an algorithm for clinical management of the different clinical stages of the HTLV-1-infection based on serum biomarkers. A panel of serum biomarkers was evaluated by four sets of innovative/non-conventional data analysis approaches in samples from 87 HTLV-1 patients: asymptomatic carriers (AC), putative HTLV-1 associated myelopathy/tropical spastic paraparesis (pHAM/TSP) and HAM/TSP. The analysis of cumulative curves and molecular signatures pointed out that HAM/TSP presented a pro-inflammatory profile mediated by CXCL10/LTB-4/IL-6/TNF-α/IFN-γ, counterbalanced by IL-4/IL-10. The analysis of biomarker networks showed that AC presented a strongly intertwined pro-inflammatory/regulatory net with IL-4/IL-10 playing a central role, while HAM/TSP exhibited overall immune response toward a predominant pro-inflammatory profile. At last, the classification and regression trees proposed for clinical practice allowed for the construction of an algorithm to discriminate AC, pHAM and HAM/TSP patients with the elected biomarkers: IFN-γ, TNF-α, IL-10, IL-6, IL-4 and CysLT. These findings reveal a complex interaction among chemokine/leukotriene/cytokine in HTLV-1 infection and suggest the use of the selected but combined biomarkers for the follow-up/diagnosis of disease morbidity of HTLV-1-infected individuals. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro e Pesquisas René Rachou. Belo Horizonte, MG, Brazil / Fundação Centro de Hematologia e Hemoterapia e Minas Gerais. Belo Horizonte, MG , Brazil / Universidade Federal e Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Patologia Anatômica. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Universidade Federal de Minas Gerais. Faculdade de Medicina. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Hospital Sarah Kubitschek. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil / Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Laboratório de Inflamação e Imunologia. Ribeirão Preto, SP, Brazil. | pt_BR |
Affilliation | Universidade De São Paulo. Faculdade de Ciências Farmacêuticas. Laboratório De Inflamação E Imunologia. Ribeirão Preto, SP, Brazil. | pt_BR |
Affilliation | Fundação Centro de Hematologia e Hemoterapia de Minas Gerais. Belo Horizonte, MG, Brazil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brazil. | pt_BR |
Subject | Chemokines | pt_BR |
Subject | HAM/TSP | pt_BR |
Subject | cytokines and morbidity | pt_BR |
Subject | leukotrienes | pt_BR |
Embargo date | 2021-01-01 | |