Author | Espíndola, Milena Sobral | |
Author | Lima, Leonardo Judson Galvão de | |
Author | Soares, Luana Silva | |
Author | Cacemiro, Maira da Costa | |
Author | Zambuzi, Fabiana Albani | |
Author | Gomes, Matheus de Souza | |
Author | Amaral, Laurence Rodrigues do | |
Author | Bollela, Valdes Roberto | |
Author | Martins Filho, Olindo Assis | |
Author | Frantz, Fabiani Gai | |
Access date | 2018-02-16T16:08:25Z | |
Available date | 2018-02-16T16:08:25Z | |
Document date | 2015 | |
Citation | ESPÍNDOLA, Milena Sobral et al. Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients. PLoS ONE, v. 10, n. 12, e0145261, 2015 | pt_BR |
ISSN | 1932-6203 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24863 | |
Language | eng | pt_BR |
Publisher | Public Library of Science | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | terapias antiretroviral | pt_BR |
Subject in Portuguese | biomarcadores | pt_BR |
Subject in Portuguese | HIV | pt_BR |
Title | Dysregulated Immune Activation in Second-Line HAART HIV+ Patients Is Similar to That of Untreated Patients | pt_BR |
Type | Article | pt_BR |
DOI | 10.1371/journal.pone.0145261 | |
Abstract | Background:Successful highly active antiretroviral therapy (HAART) has changed the outcome of AIDS patients worldwide because the complete suppression of viremia improves health and prolongs life expectancy of HIV-1+ patients. However, little attention has been given to the immunological profile of patients under distinct HAART regimens. This work aimed to investigate the differences in the immunological pattern of HIV-1+ patients under the first- or second-line HAART in Brazil.
Methods:CD4+ T cell counts, Viral load, and plasma concentration of sCD14, sCD163, MCP-1, RANTES, IP-10, IL-1β, IL-6, TNF-α, IL-12, IFN-α, IFN-γ, IL-4, IL-5, and IL-10 were assessed for immunological characterization of the following clinical groups: Non-infected individuals (NI; n = 66), HIV-1+ untreated (HIV; n = 46), HIV-1+ treated with first-line HAART (HAART 1; n = 15); and HIV-1+ treated with second-line HAART (HAART 2; n = 15).
Results:We found that the immunological biosignature pattern of HAART 1 is similar to that of NI individuals, especially in patients presenting slow progression of the disease, while patients under HAART 2 remain in a moderate inflammatory state, which is similar to that of untreated HIV patients pattern. Network correlations revealed that differences in IP-10, TNF-α, IL-6, IFN-α, and IL-10 interactions were primordial in HIV disease and treatment. Heat map and decision tree analysis identified that IP-10>TNF-α>IFN-α were the best respective HAART segregation biomarkers.
Conclusion:HIV patients in different HAART regimens develop distinct immunological biosignature, introducing a novel perspective into disease outcome and potential new therapies that consider HAART patients as a heterogeneous group. | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Universidade Federal de Uberlandia. Laboratorio de Bioinformatica e Analises Moleculares. Patos de Minas, MG, Brazil | pt_BR |
Affilliation | Universidade Federal de Uberlandia. Laboratorio de Bioinformatica e Analises Moleculares. Patos de Minas, MG, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Medicina de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Rene Rachou. Laboratorio de Biomarcadores para Diagnostico e Monitoramento, Belo Horizonte, MG, Brazil | pt_BR |
Affilliation | Universidade de Sao Paulo. Faculdade de Ciencias Farmaceuticas de Ribeirao Preto. Ribeirao Preto, SP, Brazil | pt_BR |
Subject | Highly-active antiretroviral therapy | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | HIV | pt_BR |
Subject | Cytokines | pt_BR |
Subject | T cells | pt_BR |
Subject | Inflammatory diseases | pt_BR |
Subject | Viral load | pt_BR |
Subject | Decision trees | pt_BR |