Author | Bomfim, Lays Gisele Santos | |
Author | Magalhães, Lucas S | |
Author | Santos Filho, Marcello Augusto Anchieta | |
Author | Peres, Nalu Teixeira de Aguiar | |
Author | Corrêa, Cristiane B | |
Author | Tanajura, Diego Moura | |
Author | Silva, Angela Maraia da | |
Author | Lipscomb, Michael W | |
Author | Borges, Valéria de Matos | |
Author | Jesus, Amélia Ribeiro de | |
Author | Almeida, Roque Pacheco de | |
Author | Moura, Tatiana Rodrigues de | |
Access date | 2018-02-27T14:05:57Z | |
Available date | 2018-02-27T14:05:57Z | |
Document date | 2017 | |
Citation | BOMFIM, L. G. S. et al. Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis. Frontiers in Microbiology, v. 8, Article 2265, 2017. | pt_BR |
ISSN | 1664-302X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/24965 | |
Sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), MCTI/CNPQ/Universal 14/2014—460743/2014-7 (TdM) and PROCAD/CASADINHO—n◦552721/2011-5 (RA); Fundação de
Apoio à Pesquisa e à Inovação Tecnológica do Estado de Sergipe FAPITEC/SE/FUNTEC/CNPq n◦12/2009—019.203.02712/2009-8 (AJ); Coordenação de Aperfeiçoamento de Pessoal de Nível
Superior (CAPES), Programa Nacional de Incentivo à Pesquisa em Parasitologia Básica, Edital No 032/2010 (AJ); National Institute Health, NIH Grant# SC2GM103741 (ML); Department of Defense, DOD Grant# W911NF-14-1-0123, (ML); and National Science Foundation, NSF Grant# 1428768, (ML). | pt_BR |
Language | eng | pt_BR |
Publisher | Frontiers Media | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose visceral | pt_BR |
Subject in Portuguese | Leishmania infantum | pt_BR |
Subject in Portuguese | Neutrófilos | pt_BR |
Subject in Portuguese | sTREM-1 | pt_BR |
Subject in Portuguese | TREM-1 | pt_BR |
Title | Leishmania infantumInduces the Release of sTREM-1 in Visceral Leishmaniasis | pt_BR |
Type | Article | pt_BR |
DOI | 10.3389/fmicb.2017.02265 | |
Abstract | Visceral leishmaniasis (VL) is a systemic transmissible disease that remains to be a major global health problem. The inflammatory response during VL is characterized by the release of several cytokines and other pro-inflammatory mediators. Triggering Receptor Expressed on Myeloid Cells (TREM) are a group of evolutionarily conserved membrane-bound surface receptors expressed on neutrophils and monocytes. Engagement of TREM-1 directs intracellular signaling events that drive cytokine production, degranulation, and phagocytosis. In certain inflammatory-associated diseases, TREM-1 can also be found as a soluble form (sTREM-1), which can negatively regulate TREM-1 receptor signaling. In these studies, we now find that high levels of circulating sTREM-1 correlate directly with VL disease severity. In particular, high levels of sTREM-1 were observed in non-survivor VL patients. Furthermore, these levels of sTREM-1 positively correlated with liver size and negatively correlated with leukocyte counts and hemoglobin concentration. Moreover, we found that neutrophils exposurein vitrotoLeishmania infantummodulates TREM-1, DAP12, and IL-8 gene expression, while also increasing release of sTREM-1. Finally, results revealed that higher sTREM-1 levels are associated with increasing parasite ratio. Taken together, these studies suggest thatL. infantummay modulate TREM-1 in neutrophils and high levels of this molecule is associated with severe VL. | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Howard University. Department of Biology. Washington, DC, USA | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Affilliation | Universidade Federal de Sergipe. Hospital Universitário. Laboratório de Biologia Molecular. Aracaju, SE, Brasil | pt_BR |
Subject | Visceral leishmaniasis | pt_BR |
Subject | Leishmania infantum | pt_BR |
Subject | Neutrophils | pt_BR |
Subject | sTREM-1 | pt_BR |
Subject | TREM-1 | pt_BR |