Author | Costa, Rúbia Suely Santana | |
Author | Carvalho, Lucas Pedreira de | |
Author | Britto, Taís Menezes Cerqueira Campos de | |
Author | Magalhães, Andréa S | |
Author | Passos, Sara Timoteo | |
Author | Schriefer, Albert | |
Author | Silva, Juliana A | |
Author | Lago, Ednaldo | |
Author | Paixão, Camilla Santos | |
Author | Machado, Paulo Roberto Lima | |
Author | Scott, Phillip | |
Author | Carvalho Filho, Edgar Marcelino | |
Access date | 2018-02-28T17:51:42Z | |
Available date | 2018-02-28T17:51:42Z | |
Document date | 2018 | |
Citation | COSTA, R. S. S. et al. Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy. The Journal of Infectious Diseases, v. 217, p. 840–850, 2018. | pt_BR |
ISSN | 0022-1899 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25002 | |
Sponsorship | National Institutes of Health (Grant U01 AI088650-06) | pt_BR |
Language | eng | pt_BR |
Publisher | University of Chicago Press | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Leishmaniose cutânea precoce | pt_BR |
Subject in Portuguese | Quimiocinas | pt_BR |
Subject in Portuguese | Leishmaniose cutânea | pt_BR |
Subject in Portuguese | Leishmania braziliensis | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Title | Early Cutaneous Leishmaniasis Patients Infected With Leishmania braziliensis Express Increased Inflammatory Responses After Antimony Therapy | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/infdis/jix627 | |
Abstract | Early cutaneous leishmaniasis (ECL) is characterized by a nonulcerated papular lesion and illness duration less than 30 days. Approximately 4 weeks later, the cutaneous leishmaniasis (CL) ulcers appear. We were surprised to find that failure after antimony therapy (Sb5) is higher in ECL than CL. We hypothesize that the inflammatory response in ECL patients may increase during Sb5 therapy, which leads to treatment failure. Methods. A cohort of 44 ECL patients infected by Leishmania braziliensis was established to evaluate the response to Sb5 and to
compare immunologic responses in ECL patients with CL and healthy subjects.
Results. A hierarchical clustering based on cytokine levels showed a weak positive correlation between proinflammatory cytokine
levels and those patients that failed Sb5 treatment. Although Sb5 therapy decreased interferon-γ and tumor necrosis factor levels
in CL patients, we were surprised to find that an increase in these cytokines was observed in ECL patients. Moreover, interleukin
(IL)-10 was less able to down-modulate immune responses in ECL.
Conclusions. The enhanced production of proinflammatory cytokines, due in part to the decreased ability of IL-10 to down-modulate
immune response during therapy in ECL, promotes the development and persistence of leishmania ulcer despite antimony
therapy. | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / University of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PA | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Pennsylvania. School of Veterinary Medicine. Department Pathobiology. Philadelphia, PA | pt_BR |
Affilliation | Universidade Federal da Bahia. Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Salvador, BA, Brasil | pt_BR |
Subject | Early cutaneous leishmaniasis | pt_BR |
Subject | Chemokines | pt_BR |
Subject | Cutaneous leishmaniasis | pt_BR |
Subject | Leishmania braziliensis | pt_BR |
Subject | Cytokines | pt_BR |