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E-CADHERIN REGULATORS ARE DIFFERENTIALLY EXPRESSED IN THE EPITHELIUM AND STROMA OF KERATOCYSTIC ODONTOGENIC TUMORS
E-caderina
Transição epitelial-mesenquimal
Imuno-histoquímica
Tumores odontogênicos
E-cadherin
Epithelial–mesenchymal transition
Immunohistochemistry
Odontogenic tumors
Autor
Afiliación
Federal University of Bahia. School of Dentistry. Pos-graduate of Dentistry and Health. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Social and Pediatric Dentistry. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Pos-graduate of Dentistry and Health. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
University of São Paulo. Institute of Biomedical Sciences. Department of Anatomy, Extracellular Matrix Biology and Cellular Interaction Laboratory. São Paulo, SP, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Social and Pediatric Dentistry. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Pos-graduate of Dentistry and Health. Salvador, BA, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Salvador, BA, Brazil
University of São Paulo. Institute of Biomedical Sciences. Department of Anatomy, Extracellular Matrix Biology and Cellular Interaction Laboratory. São Paulo, SP, Brazil
Federal University of Bahia. School of Dentistry. Department of Propaedeutics and Integrated Clinical Practicum. Surgical Pathology Laboratory. Salvador, BA, Brazil
Resumen en ingles
The epithelial-mesenchymal transition (EMT) is the process where cells lose their epithelial features and acquire properties of typical mesenchymal cells. The dissociation of tumor cells due to changes in cell-cell adhesion is one of the key principles of tumor invasion and EMT. Thus, the knowledge of the molecular features of EMT in keratocyst odontogenic tumor (KOT) can provide useful markers to aid in the diagnosis and prognosis and perhaps contribute to an alternative therapeutic approach as it shows an aggressive clinical behavior and high recurrence rates. This study aimed to evaluate the EMT in KOT by the immunoexpression of E-cadherin, N-cadherin, Snail, and Slug and comparing to radicular cysts and dental follicles.
Palabras clave en portugues
Adesão celularE-caderina
Transição epitelial-mesenquimal
Imuno-histoquímica
Tumores odontogênicos
Palabras clave en ingles
Cell adhesionE-cadherin
Epithelial–mesenchymal transition
Immunohistochemistry
Odontogenic tumors
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