Author | Carvalho, Natália Barbosa | |
Author | Bastos, Maria de Lourdes | |
Author | Souza, Anselmo de Santana | |
Author | Martins Netto, Eduardo | |
Author | Arruda, Sérgio Marcos | |
Author | Santos, Silvane B | |
Author | Carvalho, Edgar Marcelino de | |
Access date | 2018-04-17T16:21:37Z | |
Available date | 2018-04-17T16:21:37Z | |
Document date | 2018 | |
Citation | CARVALHO, N. B. et al. Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals. Tuberculosis, v. 108, p. 35–40, 2018. | pt_BR |
ISSN | 1472-9792 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/25909 | |
Sponsorship | CNPq (473459/2012-4), Ministry of Science and Technology (573839/2008-5), CAPES (573839/2008-5), and Maria Emília Pedreira Freire de Carvalho Foundation (160067). | pt_BR |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | HTLV-1 | pt_BR |
Subject in Portuguese | Tuberculose | pt_BR |
Subject in Portuguese | Co-infecção | pt_BR |
Subject in Portuguese | Resposta imune | pt_BR |
Title | Impaired TNF, IL-1β, and IL-17 production and increased susceptibility to Mycobacterium tuberculosis infection in HTLV-1 infected individuals | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.tube.2017.10.004 | |
Abstract | IFN-γ and TNF play critical roles in the control of Mycobacterium tuberculosis infection. Despite leading to an exaggerated production of inflammatory cytokines, HTLV-1 infection increases the risk of developing tuberculosis (TB). However, the immune mechanisms accounting for this phenomenon are still unclear. The aim of this study was to evaluate immunological aspects of the HTLV-1/M. tuberculosis co-infection. In this cross-sectional study, the levels of TNF, IL-1β, and IL-17 were determined by ELISA in the supernatants of either unstimulated or tuberculin purified protein derivative (PPD) stimulated peripheral blood mononuclear cells. Cells from HTLV-1 infected individuals produced lower levels of TNF following PPD stimulation compared to unstimulated cells. IL-1β and IL-17 production by cells from HTLV-1/M. tuberculosis co-infected individuals was lower than in cells from patients with TB. Impairment in TNF, IL-1β, and IL-17 production upon stimulation with mycobacterial antigens may contribute to the increased susceptibility to M. tuberculosis infection observed in HTLV-1 infected individuals. | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Laboratório de Pesquisa em Infectologia. Salvador, BA, Brasil / Fundação José Silveira. Instituto Brasileiro para a Investigação da Tuberculose. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Universidade Estadual de Feira de Santana. Departamento de Ciências Biológicas. Feira de Santana, BA, Brasil / Ministério de Ciência Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Complexo Hospitalar Universitário Professor Edgard Santos. Serviço de Imunologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Ministério de Ciência Tecnologia e Inovação. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Conselho Nacional de Desenvolvimento Científico e Tecnológico. Salvador, BA, Brasil | pt_BR |
Subject | HTLV-1 | pt_BR |
Subject | Tuberculosis | pt_BR |
Subject | Co-infection | pt_BR |
Subject | Immune response | pt_BR |