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ANTIBODY PERSISTENCE AND EVIDENCE OF IMMUNE MEMORY AT 5YEARS FOLLOWING ADMINISTRATION OF THE 9-VALENT HPV VACCINE
Autor
Afiliación
Pablo Tobon Uribe Hospital. Research Unit. Medellin, Antioquia, Colombia
Vía Libre CRS. Lima, Peru
University Medical Center Hamburg-Eppendorf. Hamburg, Germany
Associação Obras Sociais Irma Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Medical University of Vienna. Comprehensive Cancer Center. Vienna, Austria
Medical University of Graz. Department of Obstetrics & Gynecology. Graz, Austria
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Vía Libre CRS. Lima, Peru
University Medical Center Hamburg-Eppendorf. Hamburg, Germany
Associação Obras Sociais Irma Dulce. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Medical University of Vienna. Comprehensive Cancer Center. Vienna, Austria
Medical University of Graz. Department of Obstetrics & Gynecology. Graz, Austria
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Merck & Co. Kenilworth, NJ, USA
Resumen en ingles
The 9-valent HPV (9vHPV) vaccine was developed to prevent infection and disease related to 9 HPV types (HPV6/11/16/18/31/33/45/52/58) which cause approximately 90% of cervical cancers, HPV-related vulvar, vaginal and anal cancers, and genital warts worldwide. In a pivotal efficacy study, the 9vHPV vaccine prevented infection and disease due to the 9 vaccine types. Duration of protection remains to be determined. Vaccines that induce long-term protection are generally characterized by the generation of immune memory. The purpose of this report is to assess the persistence of HPV antibody response and existence of immune memory at 5years post-vaccination.
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