Author | Jelicks, Linda A. | |
Author | Souza, Andréa P. de | |
Author | Araujo-Jorge, Tania C. | |
Author | Tanowitz, Herbert B. | |
Access date | 2018-04-26T16:00:36Z | |
Available date | 2018-04-26T16:00:36Z | |
Document date | 2011 | |
Citation | JELICKS, Linda A. et al. Would selenium supplementation aid in therapy for Chagas Disease?. Trends Parasitol., v. 27, n.3, p.102–105, Mar. 2011. | pt_BR |
ISSN | 1471-4922 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26142 | |
Language | eng | pt_BR |
Publisher | Elsevier | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Tratamento | pt_BR |
Subject in Portuguese | suplementação de selênio | pt_BR |
Title | Would selenium supplementation aid in therapy for Chagas disease? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.pt.2010.12.002 | |
Abstract | Chagas disease, a neglected tropical disease discovered over 100 years ago, is caused by the intracellular parasite Trypanosoma cruzi and is most frequently associated with chronic cardiomyopathy and digestive disorders. Initial invasion of cells is followed by progressive inflammatory destruction of heart, muscles, nerves, and gastrointestinal (GI) tract tissue. Approximately 30% of patients progress to a chronic cardiomyopathy associated with increased morbidity and mortality. Seven to 10% of patients develop megasyndromes involving the GI tract, in particular, the esophagus and the colon. Results from several studies suggest that selenium (Se) deficiency could be an important factor in the pathogenesis of Chagas disease. In this opinion article, Se supplementation is proposed as an adjuvant therapy for treatment of chronic Chagas disease. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Physiology and Biophysics. New York, NY, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inovações em Terapias, Ensino e Bioprodutos. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Albert Einstein College of Medicine. Department of Pahology and Medicine. New York, NY, USA. | pt_BR |
Subject | Chagas Disease | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | selenium supplementation | pt_BR |
Subject | therapy | pt_BR |
e-ISSN | 1471-5007 | |
Embargo date | 2030-01-01 | |