Author
Affilliation
Abstract
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
Publisher
Nature
Citation
ADEMA, Coen M et al. Whole genome analysis of a schistosomiasis-transmitting freshwater snail. Nat Commun., v. 8, art. 15451, 2017
DOI
DOI 10.1038/ncomms15451
ISSN
2041-1723
Notes
LaDeana W. Hillier
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Catherine S. Jones
Institute of Biological and Environmental Sciences. School of Biological Sciences. University of Aberdeen, AB, UK.
Eric S. Loker
Center for Theoretical and Evolutionary Immunology, Biology. University of New Mexico. Albuquerque, NM, USA.
Matty Knight
Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty. School of Medicine & Health Sciences. George Washington University. Washington, DC, USA/Division of Science & Mathematics. University of the District of Columbia. Washington, DC, USA.
Patrick Minx
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Guilherme Correa de Oliveira
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil/Instituto Tecnologico Vale. Belem, PA, Brazil.
Nithya Raghavan
10805 Tenbrook Dr Silver Spring, Maryland 20901, USA.
Andrew Shedlock
College of Charleston. Biology Department. Medical University of South Carolina College of Graduate Studies Hollings Marine Laboratory Charleston. Charleston, SC, USA.
Laurence Rodrigues do Amaral
Universidade Federal de Uberlandia. Instituto de Bioquimica. Laboratorio de Bioinformatica e Análise Molecular. Patos de Minas, MG, Brasil.
Halime D. Arican-Goktas
Department of Life Sciences. College of Health and Life Sciences. Brunel University. London, Uxbridge, UK.
Juliana de Assis Silva Gomes Estanislau
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Elio Hideo Baba
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Olga L. Baron
Institut Sophia Agrobiotech. INRA/CNRS/UNS. Sophia Antipolis, France.
Christopher J. Bayne
Department of Integrative Biology. Oregon State University. Corvallis, Oregon, USA.
Utibe Bickham-Wright
Department of Pathobiological Sciences. University of Wisconsin - School of Veterinary Medicine. Madison, Wisconsin, USA.
Kyle K. Biggar
Institute of Biochemisty and Department of Biology. Carleton University. Ottawa, Ontario, Canada.
Michael Blouin
Department of Integrative Biology. Oregon State University. Corvallis, Oregon, USA.
Bryony C. Bonning
Iowa State University. Ames, USA.
Chris Botka
Department of Information Technology. Harvard Medical School. Boston, MA, USA.
Joanna M. Bridger
Department of Life Sciences. College of Health and Life Sciences. Brunel University. London, Uxbridge, UK.
Katherine M. Buckley
Sunnybrook Health Sciences Centre. Department of Immunology. University of Toronto., Toronto, Ontario, Canada.
Sarah K. Buddenborg
Center for Theoretical and Evolutionary Immunology, Biology. University of New Mexico. Albuquerque, NM, USA.
Roberta Lima Caldeira
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Helmintologia e Malacologia Medica. Belo Horizonte, MG, Brazil.
Julia Carleton
Department of Human Genetics. University of Utah. Salt Lake City, Utah, USA.
Omar Santos Carvalho
Fundação Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Helmintologia e Malacologia Medica. Belo Horizonte, MG, Brazil.
Maria G. Castillo
Department of Biology. New Mexico State University. Las Cruces, NM, USA.
Iain W. Chalmers
Animal and Microbial Sciences Research Theme. IBERS. Aberystwyth University. Aberystwyth, UK.
Mikkel Christensens
EMBL-EBI, Wellcome Genome Campus. Hinxton. Cambridgeshire, UK.
Sandra Clifton
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Celine Cosseau
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Christine Coustau
Institut Sophia Agrobiotech. INRA/CNRS/UNS. Sophia Antipolis, France.
Richard M. Cripps
Department of Biology. University of New Mexico. Albuquerque, NM, USA.
Yesid Cuesta-Astroz
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Scott F. Cummins
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Leon Di Stefano
The Walter and Eliza Hall Institute for Medical Research 1G Royal Parade. Parkville, Victoria, Australia/Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli. Melanoma Research Fellow Peter MacCallum Cancer Centre St Andrews Place. East Melbourne, Victoria, Australia
Nathalie Dinguirard
Department of Pathobiological Sciences. University of Wisconsin - School of Veterinary Medicine. Madison, Wisconsin, USA.
David Duval
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Scott Emrich
Genomics and Bioinformatics Core Facility. 19 Galvin Life Sciences. University of Notre Dame. Notre Dame, Indiana, USA.
Cedric Feschotte
Department of Human Genetics. University of Utah. Salt Lake City, Utah, USA.
Rene Feyereisen
University of Copenhagen. Faculty of Science. Department of Plant and Environmental Sciences. Thorvaldsensvej 40, 1871 Frederiksberg C, Denmark.
Peter FitzGerald
Genome Analysis Unit. National Cancer Institute. National Institutes of Health. Bethesda, Maryland, USA.
Catrina Fronick
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Lucinda Fulton
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Richard Galinier
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Sandra Grossi Gava
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Michael Geusz
Biological Sciences. Bowling Green State University. Bowling Green, Ohio, USA.
Kathrin K. Geyer
Animal and Microbial Sciences Research Theme. IBERS. Aberystwyth University. Aberystwyth, UK.
Gloria I. Giraldo-Calderon
Genomics and Bioinformatics Core Facility. 19 Galvin Life Sciences. University of Notre Dame. Notre Dame, Indiana, USA.
Matheus de Souza Gomes
Universidade Federal de Uberlandia. Instituto de Bioquimica. Laboratorio de Bioinformatica e Análise Molecular. Patos de Minas, MG, Brasil.
Michelle A. Gordy
Department of Public Health Sciences. University of Alberta. South Academic Building, Edmonton, Alberta, Canada.
Benjamin Gourbal
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Christoph Grunau
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Patrick C. Hanington
Department of Public Health Sciences. University of Alberta. South Academic Building, Edmonton, Alberta, Canada.
Karl F. Hoffmann
Animal and Microbial Sciences Research Theme. IBERS. Aberystwyth University. Aberystwyth, UK.
Daniel Hughes
EMBL-EBI, Wellcome Genome Campus. Hinxton. Cambridgeshire, UK.
Judith Humphries
Department of Biology. Lawrence University. Appleton, Wisconsin, USA.
Daniel J. Jackson
Courant Research Centre Geobiology. Georg-August University of Gottingen, Goldschmidtstrae 3, 37077 Gottingen, Germany.
Liana Konovaloff Jannotti Passos
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Wander de Jesus Jeremias
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Susan Jobling
Institute of Environment, Health & Societies, Environment and Health Theme. Brunel University London. Uxbridge UB8 3PH, UK.
Bishoy Kamel
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Aurelie Kapusta
Department of Human Genetics. University of Utah. Salt Lake City, Utah, USA.
Satwant Kaur
Institute of Environment, Health & Societies, Environment and Health Theme. Brunel University London. Uxbridge UB8 3PH, UK.
Joris M. Koene
Faculteit der Aard- enLevenswetenschappen. Vrije Universiteit. De Boelelaan 1085-1087, 1081 HV Amsterdam, The Netherlands.
Andrea B. Kohn
The Whitney Laboratory for Marine Bioscience. University of Florida. 9505 Ocean Shore Blvd, St Augustine, Florida 32080, USA.
Dan Lawson
EMBL-EBI, Wellcome Genome Campus. Hinxton. Cambridgeshire, UK.
Scott P. Lawton
Molecular Parasitology Laboratory. School of Life Sciences Pharmacy and Chemistry. Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK.
Di Liang
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Yanin Limpanont
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Sijun Liu
Iowa State University. Ames, USA.
Anne E. Lockyer
Institute of Environment, Health & Societies, Environment and Health Theme. Brunel University London. Uxbridge UB8 3PH, UK.
TyAnna L. Lovato
Department of Biology. University of New Mexico. Albuquerque, NM, USA
Fernanda Ludolf Ribeiro
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Vince Magrini
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Donald P. McManus
Molecular Parasitology Laboratory. QIMR Berghofer Medical Research Institute. Brisbane, Queensland 4006, Australia.
Monica Medina
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA.
Milind Misra
Center for Theoretical and Evolutionary Immunology, Biology. University of New Mexico. Albuquerque, NM, USA.
Guillaume Mitta
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Gerald M. Mkoji
Kenya Medical Research Institute. Nairobi, Kenya.
Michael J. Montague
Department of Neuroscience. Perelman School of Medicine at the University of Pennsylvania. Philadelphia, Pennsylvania 19104, USA.
Cesar Montelongo
Department of Biology. New Mexico State University. Las Cruces, NM, USA.
Leonid L. Moroz
The Whitney Laboratory for Marine Bioscience. University of Florida. 9505 Ocean Shore Blvd, St Augustine, Florida 32080, USA.
Monica C. Munoz-Torres
Berkeley Bioinformatics Open-Source Projects. Environmental Genomics and Systems Biology Division. Lawrence Berkeley National Laboratory. Berkeley, CA, USA
Umar Niazi
Animal and Microbial Sciences Research Theme. IBERS. Aberystwyth University. Aberystwyth, UK.
Leslie R. Noble
Institute of Biological and Environmental Sciences. School of Biological Sciences. University of Aberdeen, AB, UK.
Francislon Silva de Oliveira
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Fabiano Sviatopolk Mirsky Pais
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Anthony T. Papenfuss
The Walter and Eliza Hall Institute for Medical Research 1G Royal Parade. Parkville, Victoria, Australia/Bioinformatics and Cancer Genomics lab Lorenzo and Pamela Galli. Melanoma Research Fellow Peter MacCallum Cancer Centre St Andrews Place. East Melbourne, Victoria, Australia.
Rob Peace
Department of Systems and Computer Engineering. Carleton University. Ottawa, Ontario, Canada K1S 5B6.
Janeth J. Pena
Center for Theoretical and Evolutionary Immunology, Biology. University of New Mexico. Albuquerque, NM, USA.
Emmanuel A. Pila
Department of Public Health Sciences. University of Alberta. South Academic Building, Edmonton, Alberta, Canada.
Titouan Quelais
Univ. Perpignan Via Domitia. IHPE UMR 5244. CNRS. IFREMER, Univ. Montpellier, Perpignan, France.
Brian J. Raney
Genomics Institute. UC Santa Cruz. Santa Cruz, CA, USA.
Jonathan P. Rast
Sunnybrook Health Sciences Centre. Department of Immunology. University of Toronto., Toronto, Ontario, Canada.
David Rollinson
Parasites and Vectors Division. London Centre for Neglected Tropical Disease Research, Wolfson Wellcome
Izinara Cruz Rosse
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Bronwyn Rotgans
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Edwin J. Routledge
Institute of Environment, Health & Societies, Environment and Health Theme. Brunel University London. Uxbridge UB8 3PH, UK.
Kathryn M. Ryan
Department of Biology. University of New Mexico. Albuquerque, NM, USA
Larissa Lopes Silva Scholte
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil
Kenneth B. Storey
Institute of Biochemisty and Department of Biology. Carleton University. Ottawa, Ontario, Canada.
Martin Swain
Animal and Microbial Sciences Research Theme. IBERS. Aberystwyth University. Aberystwyth, UK.
Jacob A. Tennessen
Department of Integrative Biology. Oregon State University. Corvallis, Oregon, USA.
Chad Tomlinson
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Damian L. Trujillo
Department of Biology. University of New Mexico. Albuquerque, NM, USA
Emanuela V. Volpi
Department of Biomedical Sciences. Faculty of Science and Technology. University of Westminster. London W1W 6UW, UK.
Anthony J. Walker
Molecular Parasitology Laboratory. School of Life Sciences Pharmacy and Chemistry. Kingston University, Kingston upon Thames, Surrey KT1 2EE, UK.
Tianfang Wang
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Ittiprasert Wannaporn
Department of Microbiology, Immunology & Tropical Medicine and Research Center for Neglected Diseases of Poverty. School of Medicine & Health Sciences. George Washington University. Washington, DC, USA
Wesley C. Warren
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
Xiao-Jun Wu
Department of Pathobiological Sciences. University of Wisconsin - School of Veterinary Medicine. Madison, Wisconsin, USA.
Timothy P. Yoshino
Department of Pathobiological Sciences. University of Wisconsin - School of Veterinary Medicine. Madison, Wisconsin, USA.
Mohammed Yusuf
London Centre for Nanotechnology. University College London. London WC1E 6BT, UK/Research Complex at Harwell. Rutherford Appleton Laboratory. Oxfordshire, UK
Si-Ming Zhang
Center for Theoretical and Evolutionary Immunology, Biology. University of New Mexico. Albuquerque, NM, USA.
Min Zhao
Faculty of Science. Health and Education. University of the Sunshine Coast. Maroochydore, Queensland, Australia.
Richard K. Wilson
The McDonnell Genome Institute. Washington University. Saint Louis, Missouri, USA.
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