Author | Faria, Robson Xavier | |
Author | Souza, André Luis Almeida | |
Author | Lima, Bárbara | |
Author | Tietbohl, Luis Armando Candido | |
Author | Fernandes, Caio Pinho | |
Author | Amaral, Raquel Rodrigues | |
Author | Ruppelt, Bettina Monika | |
Author | Santos, Marcelo Guerra | |
Author | Rocha, Leandro | |
Access date | 2018-05-30T16:41:32Z | |
Available date | 2018-05-30T16:41:32Z | |
Document date | 2017 | |
Citation | FARIA, Robson Xavier; et al. Plants of Brazilian restingas with tripanocide activity against Trypanosoma cruzi strains. J. Bioenerg. Biomembr, v.49, p.473-483, 2017. | pt_BR |
ISSN | 0145-479X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26687 | |
Language | eng | pt_BR |
Publisher | Springer Verlag (Germany) | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Doença de Chagas | pt_BR |
Subject in Portuguese | Plantas | pt_BR |
Subject in Portuguese | Restingas brasileiras | pt_BR |
Title | Plants of Brazilian restingas with tripanocide activity against Trypanosoma cruzi strains | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007%2Fs10863-017-9733-9 | |
Abstract | ChagasdiseaseiscausedbytheTrypanosomacruzi affectingmillionsofpeople,andwidespreadthroughoutLatin America. This disease exhibits a problematic chemotherapy. Benznidazole, which is the drug currently used as standard treatment, lamentably evokes several adverse reactions. Among other options, natural products have been tested to discover a novel therapeutic drug for this disease. A lot of plants from the Brazilian flora did not contain studies about theirbiologicaleffects.RestingadeJurubatibafromBrazilisa sandbankecosystempoorlystudiedinrelationtoplantbiological activity. Thus, three plant species from Restinga de Jurubatiba were tested against in vitro antiprotozoal activity. Amongsixextractsobtainedfromleavesandstempartsand2
essential oils derived from leave parts, only 3 extracts inhibited epimastigote proliferation. Substances present in the extracts with activity were isolated (quercetin, myricetin, and ursolic acid), and evaluated in relation to antiprotozoal activityagainstepimastigoteYandDm28Trypanosomacruzi strains.All isolatedsubstanceswere effective toreduceprotozoalproliferation.Essentially, quercetin and myricetin did not cause mammalian cell toxicity. In summary, myricetin and quercetin molecule can be used as a scaffold to develop new effective drugs against Chagas’s disease. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxoplasmose e outras Protozooses. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Peptídeos. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Tecnologia Farmacêutica. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Tecnologia Farmacêutica. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amapá. Departamento de Ciências Biológicas e da Saúde. Laboratório de Pesquisa em Fármacos. Macapá, AP, Brasil / Universidade Federal do Amapá. Curso de Ciências Farmacêuticas. Laboratório de Nanobiotecnologia Fitofarmacêutica. Macapá,AP, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amapá. Curso de Ciências Farmacêuticas. Laboratório de Nanobiotecnologia Fitofarmacêutica. Macapá,AP, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Pró-Reitoria de Extensão. Laboratório Universitário Rodolpho Albino. Niterói, RJ, Brasil. | pt_BR |
Affilliation | niversidade do Estado do Rio de Janeiro. Campus São Gonçalo. Faculdade de Formação de Professores. Departamento de Ciências. São Gonçalo, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal Fluminense. Departamento de Tecnologia Farmacêutica. Laboratório de Tecnologia de Produtos Naturais. Niterói, RJ, Brasil. | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
Subject | Brazilian .Restingas . Plants | pt_BR |
Subject | Trypanocide | pt_BR |
Subject | Chagas Disese | pt_BR |
e-ISSN | 1573-6881 | |
Embargo date | 2030-01-01 | |