Author | Dantas, Rebeca Carolina Moraes | |
Author | Souza, Renata Oliveira de | |
Author | Valverde, Ludmila de Faro | |
Author | Vidal, Manuela Torres Andion | |
Author | Sales, Caroline Brandi Schlaepfer | |
Author | Sousa, Letícia Palmeira | |
Author | Santos, Jean Nunes dos | |
Author | Ramos, Eduardo Antônio Gonçalves | |
Author | Rocha, Clarissa Araújo Gurgel | |
Access date | 2018-06-11T18:59:13Z | |
Available date | 2018-06-11T18:59:13Z | |
Document date | 2017 | |
Citation | DANTAS, R. C. M. et al. Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 25, n. 10, p. e83-e88, 2017. | pt_BR |
ISSN | 1541-2016 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/26813 | |
Sponsorship | National Council for Scientific and Technological Development (CNPq, Brazil), grant number: 4768572011-2. | pt_BR |
Language | eng | pt_BR |
Publisher | Lippincott, Williams & Wilkins | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Mastocitoma | pt_BR |
Subject in Portuguese | Carcinoma oral de células escamosas | pt_BR |
Subject in Portuguese | Displasia epitelial oral | pt_BR |
Subject in Portuguese | Densidade de mastócitos | pt_BR |
Subject in Portuguese | Triptase de mastócitos | pt_BR |
Title | Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma | pt_BR |
Type | Article | pt_BR |
Abstract | The objective of this study was to compare mast cell
density (MCD) in oral epithelial dysplasias (OED) and oral squamous
cell carcinoma (OSCC) and determine its correlation with
clinical and histopathologic parameters and the degree of tumor
differentiation. Thirty OSCC samples, 14 OED samples, and 4
non-neoplastic oral mucosa samples were analyzed by immunohistochemistry
to determineMCD based on the expression of
MC tryptase. In addition, MCs were categorized morphologically
into degranulated and granulated cells. MCD was significantly
higher in OSCC lesions with a greater degree of differentiation
(P=0.04). No significant difference inMCD was detected between
mild and moderate OED samples (P=0.09). Our findings indicate
that MCs are present in the tumor microenvironment and may be
associated with a better prognosis | pt_BR |
Affilliation | University of Bahia. School of Dentistry. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Bahia. Institute of Health Science. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, Brazil | pt_BR |
Subject | Mast cell | pt_BR |
Subject | Oral squamous cell carcinoma | pt_BR |
Subject | Oral epithelial dysplasia, | pt_BR |
Subject | Mast cell density | pt_BR |
Subject | Mast cell tryptase | pt_BR |