| Author | Coelho, Miguel B. | |
| Author | Ascher, David Benjamin | |
| Author | Gooding, Clare | |
| Author | Lang, Emma | |
| Author | Maude, Hannah | |
| Author | Turner, David | |
| Author | Llorian, Miriam | |
| Author | Pires, Douglas Eduardo Valente | |
| Author | Attig, Jan | |
| Author | Smith, Christopher W.J. | |
| Access date | 2018-06-18T17:55:57Z | |
| Available date | 2018-06-18T17:55:57Z | |
| Document date | 2016 | |
| Citation | COELHO, Miguel B et al. Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. Biochem. Soc. Trans., v. 44, p. 1058-1065, 2016 | pt_BR |
| ISSN | 0300-5127 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/26929 | |
| Language | eng | pt_BR |
| Publisher | Portland Press | pt_BR |
| Rights | restricted access | pt_BR |
| Subject in Portuguese | emenda alternativa | pt_BR |
| Subject in Portuguese | ribonucleoproteína nuclear heterogênea (hnRNP) | pt_BR |
| Subject in Portuguese | Matrin3 | pt_BR |
| Subject in Portuguese | proteína de ligação do trato de polipirimidina | pt_BR |
| Title | Functional interactions between polypyrimidine tract binding protein and PRI peptide ligand containing proteins. | pt_BR |
| Type | Article | pt_BR |
| DOI | 10.1042/BST20160080 | |
| Abstract | Polypyrimidine tract binding protein (PTBP1) is a heterogeneous nuclear ribonucleoprotein (hnRNP) that plays roles in most stages of the life-cycle of pre-mRNA and mRNAs in the nucleus and cytoplasm. PTBP1 has four RNA binding domains of the RNA recognition motif (RRM) family, each of which can bind to pyrimidine motifs. In addition, RRM2 can interact via its dorsal surface with proteins containing short peptide ligands known as PTB RRM2 interacting (PRI) motifs, originally found in the protein Raver1. Here we review our recent progress in understanding the interactions of PTB with RNA and with various proteins containing PRI ligands. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K./Fundacao Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil | pt_BR |
| Affilliation | Department of Molecular Neuroscience. UCL Institute of Neurology. Queen Square, London WC1N 3BG, U.K. | pt_BR |
| Affilliation | Department of Biochemistry.University of Cambridge.Tennis Court Road, Cambridge CB2 1QW, U.K. | pt_BR |
| Subject | alternative splicing | pt_BR |
| Subject | heterogeneous nuclear ribonucleoprotein (hnRNP) | pt_BR |
| Subject | Matrin3 | pt_BR |
| Subject | polypyrimidine tract binding protein | pt_BR |
| Subject | PTB | pt_BR |
| Subject | RNA | pt_BR |
| Embargo date | 2100-01-01 | |
