Author | Alves, Adriano Francisco | |
Author | Vieira, Giciane Carvalho | |
Author | Gadelha, Francisco Allysson A. F. | |
Author | Silva, Luiz Henrique Agra Cavalcante | |
Author | Martins, Marco Aurélio | |
Author | Barbosa Filho, José Maria | |
Author | Piuvezam, Marcia Regina | |
Access date | 2018-06-21T16:53:33Z | |
Available date | 2018-06-21T16:53:33Z | |
Document date | 2017 | |
Citation | ALVES, Adriano Francisco et al. Milonine, an Alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae) Inhibits Histamine Release of Activated Mast Cells. Inflammation, v. 40, n. 6, p. 1-11, Dec. 2017. | pt_BR |
ISSN | 0360-3997 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27047 | |
Language | eng | pt_BR |
Publisher | Springer Verlag (Germany) | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Mastócitos | pt_BR |
Subject in Portuguese | Degranulação | pt_BR |
Subject in Portuguese | Histamina | pt_BR |
Subject in Portuguese | Alcaloides | pt_BR |
Subject in Portuguese | Menispermaceae | pt_BR |
Title | Milonine, an Alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae) Inhibits Histamine Release of Activated Mast Cells | pt_BR |
Type | Article | pt_BR |
DOI | 10.1007/s10753-017-0652-z | |
Abstract | Milonine is an alkaloid of Cissampelos sympodialis Eichl. (Menispermaceae), a plant used in the northeast of Brazil to treat allergies such as asthma, rhinitis, and other conditions. Previously, several alkaloids were isolated from its roots and leaves with pharmacological properties in asthma and acute inflammation models. Therefore, the aim of this study was to evaluate the milonine effect on mast cells degranulation in vivo and in vitro. Swiss mice (n = 8) were used in models of paw edema induced by carrageenan, compound 48/80, or histamine. One hour before challenge, the animals were treated with milonine (at different doses) or standard drugs and, at different time points, the edema formation was measured. In addition, other different methods, such as anaphylactic shock reaction and scratching behavior models both induced by compound 48/80, a mast cell degranulator, were used to assess milonine effect histamine release in vivo. Moreover, milonine effect on mast cell degranulation in vitro was also carried out. Firstly, it was observed that milonine significantly decreased the carrageenan edema formation only at the beginning of the reaction (i.e., up to 2 h after challenge). Furthermore, this alkaloid decreased the edema induced by compound 48/80, maintained the paw tissue integrity, without modulating histamine-induced paw edema. In anaphylactic shock reaction, milonine increased the time of animal survival when compared with compound 48/80 group. Milonine also significantly decreased the scratching behavior induced by compound 48/80 with decreasing of mast cell degranulation in vitro. Therefore, these data indicated that milonine presents anti-allergic properties by decreasing mast cell degranulation rather than acting on histamine effect. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil / Universidade Federal da Paraíba. Centro de Ciências da Saúde. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Inflamação. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB, Brasil. | pt_BR |
Affilliation | Universidade Federal da Paraíba. Centro de Ciências da Saúde. Laboratório de Imunofarmacologia. João Pessoa, PB, Brasil / Universidade Federal da Paraíba. Centro de Ciências da Saúde. Programa de Pós-Graduação em Produtos Naturais e Sintéticos Bioativos. João Pessoa, PB, Brasil. | pt_BR |
Subject | Milonine | pt_BR |
Subject | Mast cell | pt_BR |
Subject | Degranulation | pt_BR |
Subject | Histamine | pt_BR |
Subject | Alkaloid | pt_BR |
Subject | Cissampelos sympodialis Eichl | pt_BR |
Subject | Menispermaceae | pt_BR |
e-ISSN | 1573-2576 | |
Embargo date | 2030-01-01 | |