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HEPATITIS B VIRUS AND HEPATITIS DELTA VIRUS GENOTYPES IN OUTBREAKS OF FULMINANT HEPATITIS (LABREA BLACK FEVER) IN THE WESTERN BRAZILIAN AMAZON REGION
Autor
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University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil / Instituto Butantan. Laboratório de Imunologia Viral. São Paulo, SP, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto de Biociências. Universidade de São Paulo. São Paulo, SP, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil / Instituto Butantan. Laboratório de Imunologia Viral. São Paulo, SP, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Instituto de Biociências. Universidade de São Paulo. São Paulo, SP, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
University of São Paulo Medical School. Tropical Medicine Institute. Department of Gastroenterology. Laboratory of Tropical Hepatology and Gastroenterology. São Paulo, SP, Brazil / Instituto Evandro Chagas. Seção de Hepatologia. Belém, PA, Brasil
Resumen en ingles
The genotypes of hepatitis B (HBV) and delta (HDV) viruses circulating among fulminant hepatitis cases from the western Amazon Basin of Brazil were characterized in this study. HBV and HDV isolates were obtained from liver samples from 14 patients who developed fulminant hepatitis and died during 1978-1989. HBV DNA and HDV RNA were detected in all samples. Phylogenetic analyses of HDV sequences showed that they all clustered with previously characterized sequences of HDV genotype 3 (HDV-3). HBV genotypes F, A and D were found in 50.0, 28.6 and 21.4 % of cases, respectively. These results confirm the predominance of HDV-3 in South America and its association with the severe form of hepatitis, and the finding of the co-infection of HDV-3 with different genotypes of HBV suggests that the association between HDV-3 and HBV-F is not necessarily causally related to a more severe clinical course of infection.
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