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ArtículoDerechos de autor
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Fecha del embargo
2030-01-01
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- IOC - Artigos de Periódicos [12500]
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RAPID QUANTIFICATION OF NEURAMINIDASE INHIBITOR DRUG RESISTANCE IN INFLUENZA VIRUS QUASISPECIES
Autor
Afiliación
Health Protection Agency. Centre for Infection. London, UK.
Health Protection Agency. Centre for Infection. London, UK / University Hospitals Leicester NHS Trust. Leicester Royal Infirmary. Department of Infection and Tropical Medicine. Leicester, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.
Health Protection Agency. Centre for Infection. London, UK.
Health Protection Agency. Centre for Infection. London, UK / University Hospitals Leicester NHS Trust. Leicester Royal Infirmary. Department of Infection and Tropical Medicine. Leicester, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Rio de Janeiro, RJ. Brasil.
Health Protection Agency. Centre for Infection. London, UK.
Resumen en ingles
BACKGROUND:
Emerging resistance of influenza viruses to neuraminidase inhibitors is a concern, both in surveillance of global circulating strains and in treatment of individual patients. Current methodologies to detect resistance rely on the use of cultured virus, thus taking time to complete or lacking the sensitivity to detect mutations in viral quasispecies. Methodology for rapid detection of clinically meaningful resistance is needed to assist individual patient management and to track the transmission of resistant viruses in the community.
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