Author | Pacheco, A. G. | |
Author | Veloso, V. G. | |
Author | Nunes, E. P. | |
Author | Ribeiro, S. | |
Author | Guimarães, M. R. C. | |
Author | Lourenço, M. C. | |
Author | Mello, F. C. Q. | |
Author | Grinsztejn, Beatriz | |
Access date | 2018-07-30T18:38:17Z | |
Available date | 2018-07-30T18:38:17Z | |
Document date | 2014 | |
Citation | PACHECO, A. D. et al. Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro. International Journal of Tuberculosis and Lung Disease, v. 18, n. 12, p. 1473-1478, 2014. | pt_BR |
ISSN | 1027-3719 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27724 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Tuberculosis is associated with non-tuberculosis-related deaths among HIV/AIDS patients in Rio de Janeiro | pt_BR |
Type | Article | pt_BR |
DOI | 10.5588/ijtld.14.0181 | |
Abstract | SETTING: Human immunodeficiency virus (HIV) infected patients followed in a large cohort in Rio de Janeiro, Brazil. OBJECTIVE: To evaluate the association of tuberculosis (TB) and other covariables with non-TB-related (NTR) causes of death (CODs). DESIGN: Patients aged .18 years were followed from 1997 to 2009, until death or 31 December 2009, whichever was earlier. CODs were ascertained using a standardised algorithm. TB diagnosis and prophylaxis followed Brazilian guidelines. Poisson models were used to calculate adjusted rate ratios (aRRs). RESULTS: Of 2887 patients included in the study, 761 had TB (26.4%). NTR death rates were twice as high among patients with TB (4/100 vs. 2.09/100 patientyears).
TB was associated with NTR deaths (aRR 1.4, 95%CI 1.05–1.86, P ¼ 0.01). Highly active antiretroviral treatment (HAART) was protective against NTR (aRR 0.46, 95%CI 0.34–0.61, P , 0.001). Among
patients who had never had active TB, prophylaxis was also protective against NTR (aRR 0.45, P ¼ 0.04). The CD4 cell count increase was very modest for both TB and NTR CODs compared to those who did not die (0
vs. 249 cells, P , 0.001). CONCLUSIONS: TB was significantly associated with increased NTR CODs, indicating rapid progression of disease and increased long-term risk of mortality, probably related to persistent immunodeficiency or incomplete immune recovery. Our results confirm the
benefits of HAART and TB prophylaxis. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Doenças do Torax. Rio de Janeiro, Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Cohort | pt_BR |
Subject | Antiretroviral therapy | pt_BR |
Subject | Mortality | pt_BR |