Author | Oliveira Filho, Jamary | |
Author | Felzemburgh, Ridalva Dias Martins | |
Author | Costa, Federico | |
Author | Nery Júnior, Nivison Ruy Rocha | |
Author | Mattos, Adriana | |
Author | Henriques, Daniele Freitas | |
Author | Ko, Albert Icksang | |
Author | For The Salvador Zika Response Team | |
Access date | 2018-08-07T15:44:32Z | |
Available date | 2018-08-07T15:44:32Z | |
Document date | 2018 | |
Citation | OLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018. | pt_BR |
ISSN | 0002-9637 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/27985 | |
Sponsorship | NIH Grants RO1 NS064905, NIH R01 AI052473, U01 AI088752, and R25 TW009338,
and the Oswaldo Cruz Foundation | pt_BR |
Language | eng | pt_BR |
Publisher | American Society of Tropical Medicine and Hygiene | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika | pt_BR |
Subject in Portuguese | Virus Zika | pt_BR |
Subject in Portuguese | Transmissão | pt_BR |
Subject in Portuguese | Microcefalia | pt_BR |
Subject in Portuguese | Epilepsia | pt_BR |
Subject in Portuguese | Brasil | pt_BR |
Subject in Portuguese | Crianças | pt_BR |
Title | Seizures as a Complication of Congenital Zika Syndrome in Early Infancy | pt_BR |
Type | Article | pt_BR |
DOI | 10.4269/ajtmh.17-1020 | |
Abstract | Zika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1-23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment. | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Postgraduate Program in Health Sciences. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil | pt_BR |
Affilliation | Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil | pt_BR |
Affilliation | Hospital Geral Roberto Santos. Secretaria Estadual da Saúde da Bahia. Salvador, BA, Brasil | pt_BR |
Affilliation | Instituto Evandro Chagas. Belem, PA, Brasil | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut | pt_BR |
Affilliation | For The Salvador Zika Response Team | pt_BR |
Subject | Zika | pt_BR |
Subject | Zika Virus | pt_BR |
Subject | Transmission | pt_BR |
Subject | Microcephaly | pt_BR |
Subject | Epilepsy | pt_BR |
Subject | Brazil | pt_BR |
Subject | Children | pt_BR |