Author | Cooper, Philip J. | |
Author | Chico, Martha E. | |
Author | Vaca, Maritza G. | |
Author | Sandoval, Carlos A. | |
Author | Loor, Sofia | |
Author | Amorim, Leila Denise Alves Ferreira | |
Author | Rodrigues, Laura Cunha | |
Author | Barreto, Maurício Lima | |
Author | Strachan, David P. | |
Access date | 2018-08-08T16:56:20Z | |
Available date | 2018-08-08T16:56:20Z | |
Document date | 2018 | |
Citation | COOPER, Philip J. et al. Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age. American Journal of Respiratory and Critical Care Medicine, v. 197, n. 3, p. 364-372, 2018. | pt_BR |
ISSN | 1073-449X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28017 | |
Description | Barreto, Mauricio Lima. Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. "Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. | pt_BR |
Sponsorship | Hospital “Padre Alberto Buffoni” in Quininde´, Esmeraldas Province for their support | pt_BR |
Language | eng | pt_BR |
Publisher | American Thoracic Society | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Geohelmintos | pt_BR |
Subject in Portuguese | Atopia | pt_BR |
Subject in Portuguese | Chiado | pt_BR |
Subject in Portuguese | Asma | pt_BR |
Subject in Portuguese | Infância | pt_BR |
Title | Effect of Early-Life Geohelminth Infections on the Development of Wheezing at 5 Years of Age | pt_BR |
Type | Article | pt_BR |
DOI | 10.1164/rccm.201706-1222OC | |
Abstract | Exposures to geohelminths during gestation or early childhood may reduce risk of wheezing illness/asthma and atopy during childhood in tropical regions. Objectives: To investigate the effect of maternal and early childhood
geohelminths on development of wheeze/asthma and atopy during
the first 5 years of life.
Methods: A cohort of 2,404 neonates was followed to 5 years of age
in a rural district in coastal Ecuador. Data on wheeze were collected by
questionnaire and atopy was measured by allergen skin prick test
reactivity to 10 allergens at 5 years. Stool samples from mothers and
children were examined for geohelminths by microscopy.
Measurements and Main Results: A total of 2,090 (86.9%)
children were evaluated at 5 years. Geohelminths were observed in
45.5% of mothers and in 34.1% of children by 3 years. Wheeze and
asthma were reported for 12.6% and 5.7% of children, respectively,
whereas 14.0% had skin test reactivity at 5 years. Maternal
geohelminths were associated with an increased risk of wheeze
(adjusted odds ratio, 1.41; 95% confidence interval, 1.06–1.88),
whereas childhood geohelminths over the first 3 years of life were
associated with reduced risk of wheeze (adjusted odds ratio, 0.70; 95%
confidence interval, 0.52–0.96) and asthma (adjusted odds ratio, 0.60;
95% confidence interval, 0.38–0.94) but not skin prick test reactivity.
The effects on wheeze/asthma were greatest with later age of first
infection, were observed only in skin test–negative children, but were
not associated with parasite burden or specific geohelminths.
Conclusions: Although maternal exposures to geohelminths may
increase childhood wheeze, childhood geohelminths during the first
3 years may provide protection through a nonallergic mechanism.
Registered as an observational study (ISRCTN41239086). | pt_BR |
Affilliation | Universidad Internacional del Ecuador. Facultad de Ciencias Medicas de la Salud y la Vida. Quito, Ecuador / Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador / Institute of Infection and Immunity. London, United Kingdom. | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador. | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador. | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador. | pt_BR |
Affilliation | Laboratorio de Investigaciones FEPIS. Quininde, Esmeraldas Province, Ecuador. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
Affilliation | London School of Hygiene and Tropical Medicine. Faculty of Epidemiology and Population Health. London, United Kingdom. | pt_BR |
Affilliation | Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil. | pt_BR |
Affilliation | St. George’s University of London. Population Health Research Institute. London, United Kingdom. | pt_BR |
Subject | Geohelminths | pt_BR |
Subject | Atopy | pt_BR |
Subject | Wheeze | pt_BR |
Subject | Asthma | pt_BR |
Subject | Childhood | pt_BR |