Author | Guillermo, Landi V. C. | |
Author | Pereira, Wânia F. | |
Author | Meis, Juliana de | |
Author | Gomes, Flavia L. Ribeiro | |
Author | Silva, Elisabeth M. | |
Author | Palhares, Karina Kroll | |
Author | Takiya, Christina M. | |
Author | Lopes, Marcela F | |
Access date | 2018-08-21T11:41:05Z | |
Available date | 2018-08-21T11:41:05Z | |
Document date | 2009 | |
Citation | GUILLERMO, Landi V. C. et al. Targeting caspases in intracellular protozoan infections. Immunopharmacology and Immunotoxicology, v.31, n.2, p.159–173, 2009. | pt_BR |
ISSN | 0892-3973 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28248 | |
Language | eng | pt_BR |
Publisher | Taylor & Francis | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Trypanosoma cruzi | pt_BR |
Subject in Portuguese | Apoptose | pt_BR |
Subject in Portuguese | Imunidade | pt_BR |
Subject in Portuguese | Parasitos | pt_BR |
Title | Targeting caspases in intracellular protozoan infections | pt_BR |
Type | Article | pt_BR |
DOI | 10.1080/08923970802332164 | |
Abstract | Caspases are cysteine aspartases acting either as initiators (caspases 8, 9, and 10) or executioners (caspases 3, 6, and 7) to induce programmed cell death by apoptosis. Parasite infections by certain intracellular protozoans increase host cell life span by targeting caspase activation. Conversely, caspase activation, followed by apoptosis of lymphocytes and other cells, prevents effective immune responses to chronic parasite infection. Here we discuss how pharmacological inhibition of caspases might affect the immunity to protozoan infections, by either blocking or delaying apoptosis. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Ciências Biológicas. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | Apoptosis | pt_BR |
Subject | caspase | pt_BR |
Subject | immunity | pt_BR |
Subject | parasite | pt_BR |
Subject | Trypanosoma cruzi | pt_BR |
e-ISSN | 1532-2513 | |
Embargo date | 2030-01-01 | |