Author | Lima Junior, J. C. | |
Author | Tran, T. M. | |
Author | Meyer, E. V. S. | |
Author | Singh, B. | |
Author | De Simone, Salvatore Giovanni | |
Author | Santos, F. | |
Author | Daniel-Ribeiro, Cláudio Tadeu | |
Author | Moreno, A. | |
Author | Barnwell, J. W. | |
Author | Galinski, M. R. | |
Author | Ferreira, J. Oliveira | |
Access date | 2018-08-23T13:18:40Z | |
Available date | 2018-08-23T13:18:40Z | |
Document date | 2008 | |
Citation | LIMA JUNIOR, J. C. et al. Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals. Vaccine, v. 26, n. 51, p. 6645-6654, Dec. 2008. | pt_BR |
ISSN | 0264-410X | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28322 | |
Language | eng | pt_BR |
Publisher | Elsevier 12 Months | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Plasmodium vivax | pt_BR |
Subject in Portuguese | Malária | pt_BR |
Subject in Portuguese | Vacinas | pt_BR |
Subject in Portuguese | Noroeste da Amazônia | pt_BR |
Title | Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 9 in Northwestern Amazon individuals | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.vaccine.2008.09.029 | |
Abstract | Antibody and T-cell reactivities to Plasmodium vivax merozoite surface protein 9 (PvMSP9) were evaluated in a cross-sectional study of individuals naturally exposed to malaria infections living in Ribeirinha, a native riverine community and in Colina, a transmigrant community, Rondonia, Brazil. The antibody responses to PvMSP9-RIRIIand PvMSP9-Nt domains in Ribeirinha were higher compared with Colina and correlated with age and time of malaria exposure. IgG2 was most prevalent for PvMSP9-RII in both communities, and IgG1 was the predominant isotype for PvMSP9-Nt and PvMSP9-RIRII in Ribeirinha. IFN-gamma and IL-4 predominated in Ribeirinha, while IFN-gamma predominated in Colina. Variation in exposure to P. vivax likely accounts for the differences observed in cytokine and antibody levels between the two populations studied. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA. | pt_BR |
Affilliation | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA. | pt_BR |
Affilliation | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Proteínas e Peptídeos. Rio de Janeiro, RJ. Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Bioquímica e Biologia Molecular. Niterói, RJ, Brasil. | pt_BR |
Affilliation | Laboratório Central de Saúde Pública de Rondônia. Departamento de Entomologia. Porto Velho, RO, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University School of Medicine. Divisiond of Infectious Disease. Atlanta, GA, USA. | pt_BR |
Affilliation | Center for Disease Control and Prevention. Division of Parasitic Diseases. Atlanta, GA, USA. | pt_BR |
Affilliation | Emory University. YerkesNational Primate Research Center. Emory Vaccine Center. Atlanta, GA, USA / Emory University School of Medicine. Divisiond of Infectious Disease. Atlanta, GA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil. | pt_BR |
Subject | Plasmodium vivax | pt_BR |
Subject | Mal | pt_BR |
Subject | Vaccine | pt_BR |
Subject | Merozoite Surface Protein-9 | pt_BR |
Subject | Northwestern Amazon | pt_BR |
e-ISSN | 1873-2518 | |