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https://www.arca.fiocruz.br/handle/icict/28488
EFFECT OF CHRONIC TREATMENT WITH ROSIGLITAZONE ON LEYDIG CELL STEROIDOGENESIS IN RATS: IN VIVO AND EX VIVO STUDIES
Esteróides / biossíntese
Tiazolidinedionas / farmacologia
Peso Corporal / efeitos de drogas
Tamanho do órgão / efeitos de drogas
Fosfoproteínas / metabolismo
Avaliação de Medicamentos Pré-Clínicos
Hipoglicemiantes / efeitos adversos
Author
Affilliation
Universidade Federal Rural de Pernambuco. Department of Morphology and Physiology. Recife, PE, Brazil.
Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Instituto Aggeu Magalhães (FIOCRUZ). Centro de Tecnologias Estratégicas do Nordeste (CETENE). Ultrastructure Laboratory. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Antibiotics. Recife, PE, Brazil.
Universidade Federal de Pernambuco. Department of Physiology and Pharmacology. Recife, PE, Brazil.
Abstract
The present study was designed to examine the effect of chronic treatment with rosiglitazone - thiazolidinedione used in the treatment of type 2 diabetes mellitus for its insulin sensitizing effects - on the Leydig cell steroidogenic capacity and expression of the steroidogenic acute regulatory protein (StAR) and cholesterol side-chain cleavage enzyme (P450scc) in normal adult rats.
DeCS
Células de Leydig / efeitos de drogasEsteróides / biossíntese
Tiazolidinedionas / farmacologia
Peso Corporal / efeitos de drogas
Tamanho do órgão / efeitos de drogas
Fosfoproteínas / metabolismo
Avaliação de Medicamentos Pré-Clínicos
Hipoglicemiantes / efeitos adversos
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