Author | Naveca, Felipe Gomes | |
Author | Pontes, Gemilson Soares | |
Author | Chang, Aileen Yu-hen | |
Author | Silva, George Allan Villarouco da | |
Author | Nascimento, Valdinete Alves do | |
Author | Monteiro, Dana Cristina da Silva | |
Author | Silva, Marineide Souza da | |
Author | Abdalla, Lígia Fernandes | |
Author | Santos, João Hugo Abdalla | |
Author | Almeida, Tatiana Amaral Pires de | |
Author | Mejía, Matilde del Carmen Contreras | |
Author | Mesquita, Tirza Gabrielle Ramos de | |
Author | Encarnação, Helia Valeria de Souza | |
Author | Gomes, Matheus de Souza | |
Author | Amaral, Laurence Rodrigues | |
Author | Azevedo, Ana Carolina Campi | |
Author | Reis, Jordana Grazziela Alves Coelho dos | |
Author | Antonelli, Lis Ribeiro do Valle | |
Author | de Carvalho, Andréa Teixeira | |
Author | Martins Filho, Olindo Assis | |
Author | Ramasawmy, Rajendranath | |
Access date | 2018-09-06T14:07:17Z | |
Available date | 2018-09-06T14:07:17Z | |
Document date | 2018 | |
Citation | NAVECA, Felipe Gomes et al. Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 113, n. 6, p. 1-13, 2018. | pt_BR |
ISSN | 0074-0276 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/28586 | |
Language | eng | pt_BR |
Publisher | Fundação Oswaldo Cruz | pt_BR |
Rights | open access | pt_BR |
Subject in Portuguese | Zika virus | pt_BR |
Subject in Portuguese | CXCL10 | pt_BR |
Subject in Portuguese | Biomarcadores | pt_BR |
Subject in Portuguese | Quimiocinas | pt_BR |
Subject in Portuguese | Citocinas | pt_BR |
Title | Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage | pt_BR |
Type | Article | pt_BR |
DOI | 10.1590/0074-02760170542 | |
Abstract | BACKGROUND: Infection with Zika virus (ZIKV) manifests in a broad spectrum of disease ranging from mild illness to severe neurological complications and little is known about Zika immunopathogenesis.
OBJECTIVES: To define the immunologic biomarkers that correlate with acute ZIKV infection.
METHODS; We characterized the levels of circulating cytokines, chemokines, and growth factors in 54 infected patients of both genders at five different time points after symptom onset using microbeads multiplex immunoassay; comparison to 100 age-matched controls was performed for statistical analysis and data mining. FINDINGS; ZIKV-infected patients present a striking systemic inflammatory response with high levels of pro-inflammatory mediators. Despite the strong inflammatory pattern, IL-1Ra and IL-4 are also induced during the acute infection. Interestingly, the inflammatory cytokines IL-1β, IL-13, IL-17, TNF-α, and IFN-γ; chemokines CXCL8, CCL2, CCL5; and the growth factor G-CSF, displayed a bimodal distribution accompanying viremia. While this is the first manuscript to document bimodal distributions of viremia in ZIKV infection, this has been documented in other viral infections, with a primary viremia peak during mild systemic disease and a secondary peak associated with distribution of the virus to organs and tissues. MAIN CONCLUSIONS: Biomarker network analysis demonstrated distinct dynamics in concurrence with the bimodal viremia profiles at different time points during ZIKV infection. Such a robust cytokine and chemokine response has been associated with blood-brain barrier permeability and neuroinvasiveness in other flaviviral infections. High-dimensional data analysis further identified CXCL10, a chemokine involved in foetal neuron apoptosis and Guillain-Barré syndrome, as the most promising biomarker of acute ZIKV infection for potential clinical application. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil / Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil. | pt_BR |
Affilliation | Instituto Nacional de Pesquisas da Amazônia. Manaus, AM, Brasil. | pt_BR |
Affilliation | George Washington University. Washington DC, USA. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal do Amazonas. Programa de Pós-Graduação em Imunologia Básica e Aplicada. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Manaus, AM, Brasil. | pt_BR |
Affilliation | Hospital Adventista de Manaus. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Leônidas e Maria Deane. Programa de Pós-Graduação em Biologia da Interação Patógeno Hospedeiro. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Patos de Minas, MG, Brasil. | pt_BR |
Affilliation | Universidade Federal de Uberlândia. Patos de Minas, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil. | pt_BR |
Affilliation | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil/Universidade Nilton Lins. Manaus, AM, Brasil. | pt_BR |
Subject | Zika virus | pt_BR |
Subject | CXCL10 | pt_BR |
Subject | Biomarkers | pt_BR |
Subject | Chemokines | pt_BR |
Subject | Cytokines | pt_BR |