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FETAL DEMISE AND FAILED ANTIBODY THERAPY DURING ZIKA VIRUS INFECTION OF PREGNANT MACAQUES
Infecção
macacas grávidas
falecimento fetal
terapia com anticorpos
falhas
infection
failed antibody therapy
pregnant macaques
Fetal demise
Afiliación
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Múltipla autoria - ver em Notas
Múltipla autoria - ver em Notas
Resumen en ingles
Zika virus (ZIKV) infection of pregnant women is associated with pathologic complications of fetal development. Here, we infect pregnant rhesus macaques (Macaca mulatta) with a minimally passaged ZIKV isolate from Rio de Janeiro, where a high rate of fetal development complications was observed. The infection of pregnant macaques with this virus results in maternal viremia, virus crossing into the amniotic fluid (AF), and in utero fetal deaths. We also treated three additional ZIKV-infected pregnant macaques with a cocktail of ZIKV-neutralizing human monoclonal antibodies (nmAbs) at peak viremia. While the nmAbs can be effective in clearing the virus from the maternal sera of treated monkeys, it is not sufficient to clear ZIKV from AF. Our report suggests that ZIKV from Brazil causes fetal demise in non-human primates (NHPs) without additional mutations or confounding co-factors. Treatment with a neutralizing anti-ZIKV nmAb cocktail is insufficient to fully stop vertical transmission.
Palabras clave en portugues
Zika virusInfecção
macacas grávidas
falecimento fetal
terapia com anticorpos
falhas
Palabras clave en ingles
Zika virusinfection
failed antibody therapy
pregnant macaques
Fetal demise
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