Author | De Boni, Raquel B. | |
Author | Zheng, Lu | |
Author | Rosenkranz, Susan L. | |
Author | Sun, Xin | |
Author | Lavenberg, Jeffrey | |
Author | Cardoso, Sandra W. | |
Author | Grinsztejn, Beatriz | |
Author | La Rosa, Alberto | |
Author | Pierre, Samuel | |
Author | Severe, Patrice | |
Author | Cohn, Susan E. | |
Author | Collier, Ann C. | |
Author | Gross, Robert | |
Access date | 2018-10-03T16:18:53Z | |
Available date | 2018-10-03T16:18:53Z | |
Document date | 2016 | |
Citation | DE BONI, Raquel B. et al. Binge Drinking Is Associated with Differences in Weekday and Weekend Adherence in HIV-Infected Individuals. Drug and Alcohol Dependence, v. 159, p. 174-180, Feb. 2016. | pt_BR |
ISSN | 0376-8716 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29289 | |
Language | eng | pt_BR |
Publisher | Elsevier | |
Rights | restricted access | pt_BR |
Title | Binge drinking is associated with differences in weekday and weekend adherence in HIV-infected individuals | pt_BR |
Type | Article | pt_BR |
DOI | 10.1016/j.drugalcdep.2015.12.013 | |
Abstract | Background—Understanding patterns of antiretroviral adherence and its predictors is important for designing tailored interventions. Alcohol use is associated with non-adherence. This study aimed to evaluate: 1) if there was a difference in weekday compared with weekend adherence in HIV-infected individuals from low and middle income countries (LMIC), and 2) whether binge drinking was associated with this difference. Methods—Data from a randomized trial conducted at 9 sites in 8 LMIC were analyzed. Microelectronic monitors were used to measure adherence. Differences between weekday and weekend adherence in each quarter (successive 12-week periods) were compared using Wilcoxon signed rank tests and predictors of adherence, including baseline binge drinking, were evaluated using Generalized Estimating Equations. Results—Data from 255 participants were analyzed: 49.8% were male, median age was 37 years and 28.6% enrolled in Haiti. At study entry, only 2.7% reported illicit substance use, but 22.3% reported binge drinking at least once in the 30 days prior to enrollment. Adherence was higher on weekdays than weekends (median percent doses taken: 96.0% vs 94.4%; 93.7% vs 91.7%; 92.6% vs 89.7% and 93.7% vs 89.7% in quarters 1–4 respectively, all p<0.001). Binge drinking at baseline and time on study were both associated with greater differences between weekday and weekend adherence. Conclusions—Adherence was worse on weekends compared to weekdays: difference was small at treatment initiation, increased over time and was associated with binge drinking. Screening and new interventions to address binge drinking, a potentially modifiable behavior, may improve adherence in HIV-infected individuals in LMIC. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil / Center for Biostatistics in AIDS Research. Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Center for Biostatistics in AIDS Research. Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Center for Biostatistics in AIDS Research. Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Center for Biostatistics in AIDS Research. Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Center for Biostatistics in AIDS Research. Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Asociacion Civil Impacta Salud y Educacion. Lima, Peru. | pt_BR |
Affilliation | Institut National de Laboratoire et de Recherches. Centres Gheskio. Port au Prince, Haiti. | pt_BR |
Affilliation | Institut National de Laboratoire et de Recherches. Centres Gheskio. Port au Prince, Haiti. | pt_BR |
Affilliation | Northwestern University Feinberg School of Medicine. Chicago, IL, USA. | pt_BR |
Affilliation | University of Washington. Harborview Medical Center. Seattle, WA, USA. | pt_BR |
Affilliation | University of Pennsylvania Perelman School of Medicine. Department of Medicine (Infectious Diseases) and Center for Clinical Epidemiology and Biostatistics. Philadelphia, PA, USA. | pt_BR |
Subject | Alcohol | pt_BR |
Subject | Binge drinking | pt_BR |
Subject | HIV/AIDS | pt_BR |
Subject | Adherence | pt_BR |
Subject | Microelectronic monitors | pt_BR |
Subject | Low and middle income countries | pt_BR |