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LEISHMANIA-HOST INTERPLAY: THE EVERLASTING RIVALRY
Parasites
Signal transduction
Receptor
Chemotherapy
Evasion mechanisms
Afiliação
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Resumo em Inglês
Abstract: Parasitic protozoa of the genus Leishmania infect mammalian mononuclear phagocytic cells causing a potentially
fatal disease with a broad spectrum of clinical manifestations. The drugs of choice used in the leishmaniasis therapy
are significantly toxic, expensive and faced with a growing frequency of refractory infections. Thus the search for new
leishmanicidal compounds is urgently required. In order to perform a proper drug design and to understand the modes of
action of such compounds it is necessary to elucidade the intrincate cellular and molecular events that orchestrate the
parasite biology. To invade host cells Leishmania recruit different surface receptors that may assist engaging the microbicidal
responses. Even before gaining the intracellular millieu these pathogens can deactivate and/or subvert the phagocyte
signal transduction machinery rendering these cells permissive to infection. In the present review we attempted to approach
some of the most relevant cellular and biochemical invasion strategies employed by Leishmania parasites.
Palavras-chave em inglês
LeishmaniaParasites
Signal transduction
Receptor
Chemotherapy
Evasion mechanisms
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