Author | Erlandson, Kristine M. | |
Author | Taejaroenkul, Sineenart | |
Author | Smeaton, Laura | |
Author | Gupta, Amita | |
Author | Singini, Isaac L. | |
Author | Lama, Javier R. | |
Author | Mngqibisa, Rosie | |
Author | Firnhaber, Cynthia | |
Author | Cardoso, Sandra Wagner | |
Author | Kanyama, Cecilia | |
Author | Silva, Andre L. Machado da | |
Author | Hakim, James G. | |
Author | Kumarasamy, Nagalingeswaran | |
Author | Campbell, Thomas B. | |
Author | Hughes, Michael D. | |
Access date | 2018-10-11T14:51:50Z | |
Available date | 2018-10-11T14:51:50Z | |
Document date | 2015 | |
Citation | ERLANDSON, Kristine M. et al. A randomized comparison of anthropomorphic changes with preferred and alternative efavirenz-based antiretroviral regimens in diverse multinational settings. Open Forum Infectious Diseases, v. 2, n. 3, p. 1-7, 2015. | pt_BR |
ISSN | 2328-8957 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/29522 | |
Language | eng | pt_BR |
Rights | restricted access | pt_BR |
Title | A randomized comparison of anthropomorphic changes with preferred and alternative efavirenz-based antiretroviral regimens in diverse multinational Settings | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/ofid/ofv095 | |
Abstract | Background: Existing data on anthropomorphic changes in resource-limited settings primarily come from observational or cross-sectional studies. Data from randomized clinical trials are needed to inform treatment decisions in these areas of the world. Methods: The AIDS Clinical Trials Group Prospective Evaluation of Antiretrovirals in Resource-Limited Settings (PEARLS) study was a prospective, randomized evaluation of the efficacy of emtricitabine/tenofovir + efavirenz (FTC/TDF + EFV) vs lamivudine/zidovudine + efavirenz (3TC/ZDV + EFV) for the initial treatment of human immunodeficiency virus (HIV)-1-infected individuals from resource-diverse settings. Changes in anthropomorphic measures were analyzed using mixed-effect models for repeated measurements, using all available measurements at weeks 48, 96, and 144. Intent-to-treat results are presented; as-treated results were similar. Results: Five hundred twenty-six participants were randomized to FTC/TDF + EFV, and 519 participants were randomized to 3TC/ZDV + EFV. Significantly greater increases from baseline to week 144 were seen among those randomized to FTC/TDF + EFV vs 3TC/ZDV + EFV in all measures except waist-to-hip ratio, with the following mean changes: weight, 4.8 vs 3.0 kg; body mass index, 1.8 vs 1.1 kg/m(2); mid-arm, 1.7 vs 0.7 cm; waist, 5.2 vs 4.3 cm; hip, 3.8 vs 1.4 cm; and mid-thigh circumference, 3.1 vs 0.9 cm. There were 7 clinical diagnoses of lipoatrophy in the 3TC/ZDV + EFV arm compared with none in the FTC/TDF + EFV arm. The proportion of overweight or obese participants increased from 25% (week 0) to 42% (week 144) for FTC/TDF + EFV and from 26% to 38% for 3TC/ZDV + EFV. Conclusions: Our findings support first-line use of FTC/TDF + EFV in resource-limited settings and emphasize the need for interventions to limit weight gain among overweight or obese HIV-infected participants in all settings. | pt_BR |
Affilliation | University of Colorado. Aurora, CO, USA. | pt_BR |
Affilliation | Chiang Mai University. Chiang Mai, Thailand. | pt_BR |
Affilliation | Harvard School of Public Health. Boston, MA, USA. | pt_BR |
Affilliation | Johns Hopkins University. Baltimore, MD, USA. | pt_BR |
Affilliation | Malawi College of Medicine. Blantyre, Malawi. | pt_BR |
Affilliation | Asociación Civil Impacta Salud y Educación. Lima , Peru. | pt_BR |
Affilliation | Durban University of Technology. Enhancing Care Foundation. Durban, South Africa. | pt_BR |
Affilliation | University of the Witwatersrand. Faculty of Health Sciences. Department of Internal Medicine. Johannesberg, South Africa. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | University of North Carolina Project. Lilongwe, Malawi. | pt_BR |
Affilliation | Hospital Nossa Senhora da Conceição. Porto Alegre, RS, Brasil. | pt_BR |
Affilliation | University of Zimbabwe-Parirenyatwa. Harare, Zimbábue. | pt_BR |
Affilliation | Voluntary Health Services. YRGCARE Medical Centre. Chennai, India. | pt_BR |
Subject | Anthropomorphics | pt_BR |
Subject | Antiretroviral therapy | pt_BR |
Subject | Highly active | pt_BR |
Subject | HIV | pt_BR |
Subject | Lipodystrophy | pt_BR |
Subject | Obesity | pt_BR |
Embargo date | 2028-08-30 | |