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https://www.arca.fiocruz.br/handle/icict/30071
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ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-01-01
Coleções
- IOC - Artigos de Periódicos [12491]
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GLOBAL TRENDS IN MOLECULAR EPIDEMIOLOGY OF HIV-1 DURING 2000– 2007
Epidemiologia molecular
Vacina
Subtipo
Forma Recombinante Circulante
Recombinante
HIV
subtype
recombinant
molecular epidemiology
Autor(es)
Afiliação
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Múltiplas Instituições - ver em Notas
Múltiplas Instituições - ver em Notas
Resumo em Inglês
Objective—To estimate the global and regional distribution of HIV-1 subtypes and recombinants between 2000 and 2007. Design—Country-specific HIV-1 molecular epidemiology data were combined with estimates of the number of HIV-infected people in each country. Method—Cross-sectional HIV-1 subtyping data were collected from 65913 samples in 109 countries between 2000 and 2007. The distribution of HIV-1 subtypes in individual countries was weighted according to the number of HIV-infected people in each country to generate estimates of regional and global HIV-1 subtype distribution for the periods 2000–2003 and 2004–2007. Results—Analysis of the global distribution of HIV-1 subtypes and recombinants in the two time periods indicated a broadly stable distribution of HIV-1 subtypes worldwide with a notable increase in the proportion of circulating recombinant forms (CRFs), a decrease in unique recombinant forms (URFs), and an overall increase in recombinants. In 2004–2007, subtype C accounted for nearly half (48%) of all global infections, followed by subtypes A (12%) and B (11%), CRF02_AG (8%), CRF01_AE (5%), subtype G (5%) and D(2%). Subtypes F, H, J and K together cause fewer than 1% of infections worldwide. Other CRFs and URFs are each responsible for 4% of global infections, bringing the combined total of worldwide CRFs to 16% and all recombinants (CRFs plus URFs) to 20%. Conclusions—The global and regional distributions of individual subtypes and recombinants are broadly stable, although CRFs may play an increasing role in the HIV pandemic. The global diversity of HIV-1 poses a formidable challenge to HIV vaccine development.
Palavras-chave
HIVEpidemiologia molecular
Vacina
Subtipo
Forma Recombinante Circulante
Recombinante
Palavras-chave em inglês
Circulating Recombinant Form (CRF(HIV
subtype
recombinant
molecular epidemiology
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