Author | Nunes, Estevão Portela | |
Author | Santini-Oliveira, Marília | |
Author | Grinsztejn, Beatriz | |
Access date | 2018-11-22T14:28:14Z | |
Available date | 2018-11-22T14:28:14Z | |
Document date | 2010 | |
Citation | NUNES, E. P.; SANTINI-OLIVEIRA, M.; Grinsztejn, Beatriz Clinical use of raltegravir: a review. HIV Therapy, v. 4, n. 5, p. 531-542, 2010. | pt_BR |
ISSN | 1758-4310 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30154 | |
Language | eng | pt_BR |
Rights | restricted access | pt_BR |
Title | Clinical use of raltegravir: a review | pt_BR |
Type | Article | pt_BR |
DOI | 10.2217/HIV.10.38 | |
Abstract | In the last 5 years there have been important achievements in the field of HIV therapy with the availability of new
classes of antiretrovirals together with a new generation of old classes. Among them, the development of raltegravir,
the first commercially available component of integrase inhibitors, brought an extraordinary improvement in salvage
therapy for HIV-infected patients, allowing for virologic suppression even in multi-experienced subjects, who until
recently had limited treatment options. It was subsequently approved for initial treatment combined with a
nucleoside/nucleotide backbone, and also became an interesting option for naive HIV-infected populations. Its
unique characteristics, the limited potential for significant pharmacokinetic interactions with other drugs and
excellent safety profile have increased interest in its use in different settings. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Subject | HIV | pt_BR |
Subject | Integrase inhibitor | pt_BR |
Subject | Raltegravir | pt_BR |
Embargo date | 2025-08-30 | |