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https://www.arca.fiocruz.br/handle/icict/30172
MODELING TRANSMISSION DYNAMICS AND CONTROL OF VECTOR-BORNE NEGLECTED TROPICAL DISEASES
Tick-Borne diseases
Tropical climate
Disease transmission
Models statistical
Infectious
Affilliation
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil / Yale University. School of Public Health. New Haven, CT, USA.
Fundação Oswaldo Cruz. Presidência. Programa de Computação Cientifica. Rio de Janeiro, RJ, Brasil.
Yale University. School of Public Health. New Haven, CT, USA.
Fundação Oswaldo Cruz. Presidência. Programa de Computação Cientifica. Rio de Janeiro, RJ, Brasil.
Yale University. School of Public Health. New Haven, CT, USA.
Abstract
Neglected tropical diseases affect more than one billion people worldwide. The populations most impacted by such diseases are typically the most resource-limited. Mathematical modeling of disease transmission and cost-effectiveness analyses can play a central role in maximizing the utility of limited resources for neglected tropical diseases. We review the contributions that mathematical modeling has made to optimizing intervention strategies of vector-borne neglected diseases. We propose directions forward in the modeling of these diseases, including integrating new knowledge of vector and pathogen ecology, incorporating evolutionary responses to interventions, and expanding the scope of sensitivity analysis in order to achieve robust results.
Keywords
Neglected diseasesTick-Borne diseases
Tropical climate
Disease transmission
Models statistical
Infectious
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