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Autor | Bernardes, Lílian | |
Autor | Zani, Carlos Leomar | |
Autor | Ponto, Ione Carvalho | |
Fecha de acceso | 2018-11-26T15:46:21Z | |
Fecha de disponibilización | 2018-11-26T15:46:21Z | |
Fecha de publicación | 2013 | |
Referencia | BERNARDES,Lílian; ZANI, Carlos Leomar; PONTO, Ione Carvalho. Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery. Curr Med Chem., v. 20, n. 21, p. 2673-296, 2013. | pt_BR |
ISSN | 0929-8673 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30194 | |
Idioma | eng | pt_BR |
Editor | Bentham Science Publishers | pt_BR |
Derechos de autor | restricted access | pt_BR |
Palabras clave en Portugués | Drogas Antitrypanosomatidae | pt_BR |
Palabras clave en Portugués | doenças de tripanossomatídeos | pt_BR |
Palabras clave en Portugués | tripanotiona redutase | pt_BR |
Palabras clave en Portugués | inibidores da tripanotiona redutase | pt_BR |
Título | Trypanosomatidae diseases: from the current therapy to the efficacious role of trypanothione reductase in drug discovery | pt_BR |
Tipo del documento | Article | pt_BR |
Resumen en Inglés | According to World Health Organization (WHO), trypanosomiasis and leishmaniasis are the most challenging among the neglected tropical diseases. Comparative studies between Leishmania spp and Trypanosoma cruzi have been conducted aiming to find a broad spectrum antiprotozoal agent acting against both parasites. Among the potential molecular target, Trypanothione reductase (TR) is considered an ideal enzyme since it is involved in the unique thiol-based metabolism observed in the Trypanosomatidae family and is a validated target for the search of antitrypanosomatidae drugs. In this review we intend to describe the currently available therapy to treat trypanosomatidae diseases and to highlight important aspects of trypanothione reductase as a target for the search of new and selective inhibitors, such as tricyclic, diphenylsulfide, bicyclic and heterocyclic, polyamine, natural product, N-oxide and nitroheterocyclic, aryl β- aminocarbonyl and α,β-unsaturated carbonyl derivatives. | pt_BR |
Afiliación | Universidade Federalde Santa Catarina. Departamento de Ciências Farmacêuticas. Florianopolis, SC, Brasil | pt_BR |
Afiliación | Fundação Oswaldo Cruz. Centro de Pesquisa Rene Rachou. Belo Horizonte, MG, Brasi | pt_BR |
Afiliación | Universidade de São Paulo. Faculdade de Ciências Farmaceuticas. Ribeirão Preto, SP, Brasil | pt_BR |
Palavras clave en Inglês | Antitrypanosomatidae drugs | pt_BR |
Palavras clave en Inglês | trypanosomatidae diseases | pt_BR |
Palavras clave en Inglês | trypanothione reductase | pt_BR |
Palavras clave en Inglês | trypanothione reductase inhibitors | pt_BR |
Fecha de embargo | 2100-01-01 |