Author | Grosso, Filipa | |
Author | Carvalho, Karyne Rangel | |
Author | Quinteira, Sandra | |
Author | Ramos, Ana | |
Author | Assef, Ana Paula D'Alincourt Carvalho | |
Author | Asensi, Marise Dutra | |
Author | Peixe, Luísa | |
Access date | 2018-11-27T14:47:36Z | |
Available date | 2018-11-27T14:47:36Z | |
Document date | 2011 | |
Citation | GROSSO, Filipa; et al. OXA-23-producing Acinetobacter baumannii: a new hotspot of diversity in Rio de Janeiro?. Journal of Antimicrobial Chemotherapy, v.66, p.62-65, 2011. | pt_BR |
ISSN | 0305-7453 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30255 | |
Language | eng | pt_BR |
Publisher | Oxford University Press | pt_BR |
Rights | restricted access | pt_BR |
Subject in Portuguese | Acinetobacter baumannii | pt_BR |
Subject in Portuguese | grupos de sequências | pt_BR |
Title | OXA-23-producing Acinetobacter baumannii: a new hotspot of diversity in Rio de Janeiro? | pt_BR |
Type | Article | pt_BR |
DOI | 10.1093/jac/dkq406 | |
Abstract | Objectives: This study focused on the population structure of OXA-23-producing Acinetobacter baumannii clinical
isolates from Rio de Janeiro, Brazil.
Methods: The analysis included several genomic typing methods, including PFGE, two multilocus sequence
typing (MLST) schemes, sequence group (SG) determination and blaOXA-51-like sequencing. The genomic
context of the blaOXA-23 gene was also evaluated using I-CeuI hybridizations and PCR assays.
Results: Congruent clustering was obtained revealing four lineages. In accordance, four new sequence types
(STs) (ST131, ST132, ST133 and ST134) were obtained with the MLST-OD scheme (associated with the
Oxford Database) and four (ST79, ST15 and two new allelic profiles) with the MLST-IP scheme (developed by
the Institute Pasteur). Four SGs (SG1, SG4 and two new profiles) were identified, allowing the association of
70% of the isolates with European clone II. blaOXA-51-like sequencing revealed the presence of blaOXA-66,
blaOXA-69, blaOXA-95 and blaOXA-132.
Conclusions: Identification of new STs together with new SG profiles are findings suggestive of a local diversity
hotspot that is worth exploring. | pt_BR |
Affilliation | Universidade do Porto. Faculdade de Farmácia. Laboratório de Microbiologia. REQUIMTE. Porto, Portugal. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade do Porto. Faculdade de Farmácia. Laboratório de Microbiologia. REQUIMTE. Porto, Portugal / Centro de Investigação em Tecnologias da Saúde. IPSN, CESP). VN Famalicão, Portugal. | pt_BR |
Affilliation | Universidade do Porto. Faculdade de Farmácia. Laboratório de Microbiologia. REQUIMTE. Porto, Portugal. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil. | pt_BR |
Affilliation | Universidade do Porto. Faculdade de Farmácia. Laboratório de Microbiologia. REQUIMTE. Porto, Portugal. | pt_BR |
Subject | blaOXA-23 | pt_BR |
Subject | PFGE | pt_BR |
Subject | MLST | pt_BR |
Subject | sequence groups | pt_BR |
Subject | blaOXA-51-like | pt_BR |
Subject | Acinetobacter baumannii | pt_BR |
e-ISSN | 1460-2091 | |
Embargo date | 2030-01-01 | |