Author | Tan, Darrell H S | |
Author | Raboud, Janet M | |
Author | Kaul, Rupert | |
Author | Grinsztejn, Beatriz | |
Author | Cahn, Pedro | |
Author | Walmsley, Sharon L | |
Access date | 2018-11-28T13:41:09Z | |
Available date | 2018-11-28T13:41:09Z | |
Document date | 2010 | |
Citation | TAN, D. H. S. et al. Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial. Trials, v. 11, n. 113, 2010. | pt_BR |
ISSN | 1745-6215 | pt_BR |
URI | https://www.arca.fiocruz.br/handle/icict/30276 | |
Language | eng | pt_BR |
Rights | open access | pt_BR |
Title | Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial | pt_BR |
Type | Article | pt_BR |
DOI | 10.1186/1745-6215-11-113 | |
Abstract | Although highly active antiretroviral therapy (HAART) has dramatically decreased HIV-related morbidity and mortality, the associated costs, toxicities, and resistance risks make the potential delay of HAART initiation an attractive goal. Suppression of herpes simplex virus type 2 (HSV-2) may be a novel strategy for achieving this goal because HSV-2 is associated with clinically significant increases in HIV viral load, the primary driver of HIV disease progression. | pt_BR |
Affilliation | University Health Network. Toronto, Ontario, Canada. | pt_BR |
Affilliation | University Health Network. Toronto, Ontario, Canada. | pt_BR |
Affilliation | University Health Network. Toronto, Ontario, Canada. | pt_BR |
Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST/AIDS. Rio de Janeiro, RJ, Brasil. | pt_BR |
Affilliation | Fundación Huesped. Buenos Aires, Argentina. | pt_BR |
Affilliation | University Health Network. Toronto, Ontario, Canada. | pt_BR |
Subject | Acyclovir | pt_BR |
Subject | Antiviral Agents | pt_BR |
Subject | Clinical Protocols | pt_BR |
Subject | Disease Progression | pt_BR |
Subject | HIV-1 | pt_BR |
Subject | Herpesvirus 2 | pt_BR |