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https://www.arca.fiocruz.br/handle/icict/30560
Tipo de documento
ArtigoDireito Autoral
Acesso restrito
Data de embargo
2030-01-01
Coleções
- IOC - Artigos de Periódicos [12502]
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METHYL JASMONATE INDUCES CELL DEATH AND LOSS OF HYDROGENOSOMAL MEMBRANE POTENTIAL IN TRICHOMONAS VAGINALIS
Methyl jasmonate
Hydrogenosome
Trichomoniasis
Electron microscopy
Ultrastructure
Afiliação
Universidade Santa Úrsula. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Pós-Graduação em Ciências Biológicas. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Universidade Santa Úrsula. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ. Brasil.
Universidade Santa Úrsula. Rio de Janeiro, RJ, Brasil
Resumo em Inglês
Trichomonas vaginalis is an important human parasite of the urogenital tract. Jasmonates are a group of small lipids that are produced in plants and function as stress hormones. Naturally occurring methyl jasmonate (MJ) has been used to treat several types of cancer cells and it is cytotoxic to protistan parasites. It has been suggested that mitochondria are the target organelles of jasmonates. Here, we tested this drug against T. vaginalis. Although metronidazole has been the drug of choice for trichomoniasis, side effects from this treatment are common, and nausea and dizziness have been reported in up to 12% of patients. In addition, there has been increased recognition of resistance to metronidazole. We demonstrate here using flow cytometry, JC-1 and scanning and transmission electron microscopy that MJ induced the cell death of T. vaginalis parasites. Our results are discussed with previous findings published by others.
Palavras-chave em inglês
JasmonatesMethyl jasmonate
Hydrogenosome
Trichomoniasis
Electron microscopy
Ultrastructure
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