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https://www.arca.fiocruz.br/handle/icict/30650
EXERCISE TRAINING-INDUCED CHANGES IN MICRORNAS: BENEFICIAL REGULATORY EFFECTS IN HYPERTENSION, TYPE 2 DIABETES, AND OBESITY
Hipertensão arterial sistêmica
Diabetes mellitus tipo 2
Obesidade
Treino de exercícios
MicroRNA
Systemic arterial hypertension
Type 2 diabetes mellitus
Obesity
Exercise training
MicroRNA
Autor(es)
Afiliação
Federal University of Bahia. Multicentric Program of Post-Graduate in Biochemistry and Molecular Biology. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.
Federal University of Bahia. Multicentric Program of Post-Graduate in Biochemistry and Molecular Biology. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Bahia. Health Sciences Institute. Department of Biochemistry and Biophysics. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.
Federal University of Bahia. Multicentric Program of Post-Graduate in Biochemistry and Molecular Biology. Salvador, BA, Brazil / São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil / Federal University of Bahia. Health Sciences Institute. Department of Biochemistry and Biophysics. Salvador, BA, Brazil.
São Rafael Hospital. Center for Biotechnology and Cell Therapy. Salvador, BA, Brazil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / National Institute of Science and Technology for Regenerative Medicine. Rio de Janeiro, RJ, Brazil.
Resumo em Inglês
MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in the regulation of physiological processes, such as adaptation to physical exercise, and also in disease settings, such as systemic arterial hypertension (SAH), type 2 diabetes mellitus (T2D), and obesity. In SAH, microRNAs play a significant role in the regulation of key signaling pathways that lead to the hyperactivation of the renin-angiotensin-aldosterone system, endothelial dysfunction, inflammation, proliferation, and phenotypic change in smooth muscle cells, and the hyperactivation of the sympathetic nervous system. MicroRNAs are also involved in the regulation of insulin signaling and blood glucose levels in T2D, and participate in lipid metabolism, adipogenesis, and adipocyte differentiation in obesity, with specific microRNA signatures involved in the pathogenesis of each disease. Many studies report the benefits promoted by exercise training in cardiovascular diseases by reducing blood pressure, glucose levels, and improving insulin signaling and lipid metabolism. The molecular mechanisms involved, however, remain poorly understood, especially regarding the participation of microRNAs in these processes. This review aimed to highlight microRNAs already known to be associated with SAH, T2D, and obesity, as well as their possible regulation by exercise training.
Palavras-chave
MicroRNAsHipertensão arterial sistêmica
Diabetes mellitus tipo 2
Obesidade
Treino de exercícios
MicroRNA
Palavras-chave em inglês
MicroRNAsSystemic arterial hypertension
Type 2 diabetes mellitus
Obesity
Exercise training
MicroRNA
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